Localized linear IgA disease induced by ampicillin/sulbactam

Journal of the American Academy of Dermatology
Iakov ShimanovichD Zillikens

Abstract

We describe a patient who developed an exclusively perianal-intergluteal vesicular eruption after receiving a course of ampicillin/sulbactam. Direct immunofluorescence microscopy of perilesional skin demonstrated linear deposits of IgA along the dermal-epidermal junction. Circulating IgA autoantibodies against the 120-kd soluble ectodomain of bullous pemphigoid antigen 180 (LAD-1 autoantigen) were detected by immunoblotting. Discontinuation of the antibiotics resulted in a rapid resolution of the skin lesions. This is a most unusual case of localized drug-induced linear IgA disease.

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Citations

Oct 26, 2007·Pediatric Dermatology·Jean Chin Ching HoYoke Chin Giam
Nov 28, 2007·American Journal of Clinical Dermatology·Muhterem PolatNuran Alli
Mar 17, 2012·Indian Journal of Dermatology, Venereology and Leprology·Fabiola SchaferSergio Gonzalez
Dec 16, 2011·Journal of the American Academy of Dermatology·Giulio FortunaM Peter Marinkovich
Dec 6, 2011·Clinics in Dermatology·Freda SansaricqVesna Petronic-Rosic
Dec 17, 2008·Dermatologic Therapy·Laura AtzoriNicola Aste
Apr 27, 2007·Clinical and Experimental Dermatology·A LallyF Wojnarowska
Jul 3, 2013·The British Journal of Dermatology·J ChanalP Wolkenstein
Sep 11, 2010·Expert Review of Clinical Immunology·Esther Morena RodillaFélix Lorente Toledano
Jul 11, 2007·Current Opinion in Allergy and Clinical Immunology·Soledad LopezMiguel Blanca
Oct 27, 2016·Current Opinion in Infectious Diseases·Katherine C KonvinseJason A Trubiano
Jul 3, 2019·Pharmacy : Journal of Pharmacy, Education and Practice·Kayla R StoverJamie L Wagner

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