Localized Optical Coherence Tomography Precursors of Macular Atrophy and Fibrotic Scar in the Comparison of Age-Related Macular Degeneration Treatments Trials.

American Journal of Ophthalmology
Avni P FinnComparison of Age-Related Macular Degeneration Treatments Trials (CATT) Research Group

Abstract

To identify precursors of macular atrophy (MA) and of fibrotic scar (FS) in eyes treated with anti-vascular endothelial growth factor through pixel-mapping analysis of baseline optical coherence tomography (OCT). Design: Cross-sectional analysis. Multicenter clinical trial. 68 eyes from the Comparison of Age-Related Macular Degeneration Treatments Trials. Treatment with anti-vascular endothelial growth factor agents. The percentage of MA or FS pixels with each OCT feature at baseline, and the odds ratio for baseline pixels with an OCT feature to develop MA or FS. Retinal pigment epithelium atrophy and photoreceptor loss on OCT were highly predictive of MA at that location at years 2 and 5 (P < .0001), but accounted for only 22.5% of the ensuing atrophy at year 2 and less at year 5. Among pixels of MA at year 2, 78% were preceded by thick drusen, 54% by subretinal macular neovascularization (MNV), and 22.5% by no detectable OCT features. MNV, subretinal hyperreflective material, pigment epithelial detachment, intraretinal fluid, and sub-retinal pigment epithelium fluid were predictive of FS at that location (P values <.05). More than 75% of the pixels of FS at years 2 and 5 were preceded by pixels of baseline MNV. Most pixels of...Continue Reading

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Citations

Jun 25, 2021·Progress in Retinal and Eye Research·Ursula Schmidt-ErfurthHrvoje Bogunović

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