PMID: 2495372Apr 28, 1989Paper

Localized outbreak of penicillinase-producing Neisseria gonorrhoeae. Paradigm for introduction and spread of gonorrhea in a community

JAMA : the Journal of the American Medical Association
H H HandsfieldK K Holmes

Abstract

In King County, Washington, penicillinase-producing Neisseria gonorrhoeae infections increased from 0.8% of reported cases of gonorrhea in 1986 to 6.8% of cases in the third quarter of 1987, then stabilized at 2.7% to 3.6% of cases. Of 268 penicillinase-producing N gonorrhoeae isolates tested, 159 (59%) belonged to a single clone, as evidenced by auxotyping, protein-I serotyping, plasmid analysis, and antimicrobial susceptibility testing. As this strain spread, the predominance of cases shifted from whites to blacks and from men to equal numbers of men and women. The proportion of cases associated with illicit drug use rose steadily from 19% in the first quarter of 1987 to 82% in the fourth quarter. Sixty percent of cases occurred in prostitutes or recent sexual contacts of prostitutes. These results suggest that core gonorrhea transmitters in King County are predominantly black illicit drug users, prostitutes, and their sexual partners. These are priority target populations for behavioral intervention and other measures to control the spread of all sexually transmitted diseases, including human immunodeficiency virus infection.

Citations

Jul 1, 1990·American Journal of Public Health·R T RolfsR G Sharrar
Oct 1, 1991·American Journal of Public Health·K A Gershman, R T Rolfs
Apr 1, 1995·Antimicrobial Agents and Chemotherapy·J R SchwebkeK K Holmes
Aug 1, 1994·Genitourinary Medicine·B CribierJ C Tardieu
May 16, 1998·Genitourinary Medicine·M J van de LaarB van Klingeren
Aug 1, 2007·Sexually Transmitted Infections·Nicola Low, Helen Ward
Oct 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·V SchäferV Brade
Dec 22, 1999·Microbes and Infection·Y T van Duynhoven
Oct 2, 2003·Sexually Transmitted Diseases·Roxanne P KeraniKing K Holmes
Nov 20, 1997·AIDS·K A Fenton, T A Peterman
Oct 2, 2003·Sexually Transmitted Diseases·Sevgi O Aral, Betsy Foxman

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