Localized probiotic-guided pocket recolonization in the treatment of chronic periodontitis: a randomized controlled clinical trial.

Journal of Periodontal & Implant Science
Vikram KumarAbbas Ali Mahdi

Abstract

This randomized clinical placebo-controlled trial was conducted to evaluate the effectiveness of Lactobacillus reuteri as a probiotic in guided pocket recolonization (GPR) for the treatment of chronic periodontitis (CP) adjunctive to scaling and root planing (SRP). Forty-eight CP patients were randomly assigned to 3 treatment groups: group 1 (SRP+placebo), group 2 (SRP+single application of probiotic), and group 3 (SRP+incremental application of probiotic). Clinical parameters were evaluated at baseline and at 8, 12, and 24 weeks, whereas biochemical parameters were measured at baseline and 12 weeks. At 24 weeks, the probing pocket depth and clinical attachment level improved in all 3 groups from baseline with no significant intergroup differences; however, a statistically significant difference was observed in localized plaque and gingival scores between groups 1 and 3 (P<0.05). At 12 weeks, matrix metalloproteinase-8 (MMP-8), nitric oxide (NO), and gingipains-R (Rgps) levels improved in all 3 groups, with statistically significant differences between groups 1 and 3 for MMP-8 and NO (P<0.05), but no difference for Rgps levels. Within its limitations, the results of this study show that incremental 3-time application of L. reut...Continue Reading

References

May 1, 1992·Journal of Clinical Periodontology·H McNabbN P Lang
Apr 1, 1989·Journal of Clinical Periodontology·I B LamsterR L Oshrain
Mar 1, 1984·Journal of Clinical Periodontology·I MagnussonB Liljenberg
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·D C JenkinsS Moncada
Aug 1, 1997·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·L M GolubW V Giannobile
Aug 8, 1998·Journal of Clinical Periodontology·E WestfeltJ Lindhe
Feb 24, 2001·Clinical Oral Investigations·N OzmeriçA Uraz
Feb 1, 2002·FEMS Immunology and Medical Microbiology·Takao MukaiHitoshi Ohori
Oct 5, 2002·Oral Diseases·A C BatistaV S Lara
Feb 6, 2003·Journal of the American College of Nutrition·Hideki IshikawaToru Otani
Dec 1, 1963·Acta Odontologica Scandinavica·H LOE, J SILNESS
Oct 26, 2007·Journal of Dental Research·W TeughelsM Quirynen
Apr 22, 2008·Inflammatory Bowel Diseases·Yea Ping LinJames Versalovic
Aug 8, 2008·Journal of Clinical Gastroenterology·Rolf J Boesten, Willem M de Vos
Sep 9, 2008·Journal of Clinical Periodontology·M SanzUNKNOWN Group A of European Workshop on Periodontology
Apr 22, 2010·Journal of Indian Society of Periodontology·K B MenakaN Suchetha Kumari
Aug 21, 2013·Journal of Clinical Periodontology·Oleh AndrukhovXiaohui Rausch-Fan
Mar 6, 2015·Frontiers in Microbiology·Konstantinos PapadimitriouEffie Tsakalidou
Dec 15, 2015·Periodontology 2000·Silvana P BarrosThiago Morelli
Apr 9, 2017·Journal of Translational Medicine·Rasnik K SinghWilson Liao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.