Localized relapse in bone marrow of extremities after allogeneic stem cell transplantation for acute lymphoblastic leukemia

American Journal of Hematology
T EndoT Koike

Abstract

We report a patient with a relapsed in bone marrow of extremities after allogeneic peripheral blood stem cell transplantation for acute lymphoblastic leukemia (ALL). The patient complained of pain in the right upper arm and left leg 15 months after transplantation. Magnetic resonance imaging (MRI) and fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) showed abnormal findings in bone marrow of upper and lower extremities. There were no findings of relapse in aspirates from the sternum and iliac bone marrow. Biopsy specimen from the iliac bone marrow showed normocellular marrow without leukemic cells. Biopsy specimen from the right humerus revealed marked leukemic cell infiltration in the bone marrow. This is apparently the first case of localized relapse of ALL in bone marrow of extremities. Physicians should be aware of unusual relapse sites of leukemia after allogeneic stem cell transplantation. MRI and FDG-PET may be of value in detecting this type of relapse.

References

Jan 1, 1979·Medical and Pediatric Oncology·B GolembeW Krivit
Oct 1, 1986·The Journal of Pediatrics·N J BuninG K Rivera
Jul 5, 2003·International Journal of Hematology·Tetsuo MaedaYuji Matsuzawa
Oct 11, 2003·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Katherina KuenzleHans C Steinert

❮ Previous
Next ❯

Citations

Nov 13, 2007·Pediatric Radiology·J Herman KanSusan A Connolly
Jul 14, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Ali AgoolRiemer H J A Slart
Aug 22, 2006·Clinical Nuclear Medicine·Elinor GoshenS Tzila Zwas
May 7, 2008·Nuclear Medicine Communications·Yong LiuChunyan Chen
Oct 24, 2009·Clinical Nuclear Medicine·Kazuyoshi SugaNaofumi Matsunaga
Jun 1, 2012·Nuclear Medicine and Molecular Imaging·William MakisMarc Hickeson
Oct 27, 2006·Leukemia & Lymphoma·Isabel Cunningham
Sep 10, 2013·International Journal of Radiation Oncology, Biology, Physics·Yutaka TakahashiSusanta K Hui
Jan 1, 2016·American Journal of Hematology·Isabel Cunningham, Brigett Kohno
Sep 26, 2015·SpringerPlus·Maya Kato ArimotoKaori Togashi
Apr 20, 2016·Blood Reviews·L VallsN Avril
Oct 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daisuke EnnishiMitsune Tanimoto
Sep 3, 2020·Technology in Cancer Research & Treatment·Zixuan ZhaoShengming Deng
Dec 15, 2020·Critical Reviews in Oncology/hematology·Isabel Cunningham
Jul 18, 2021·Seminars in Nuclear Medicine·Patrick PilkingtonKen Herrmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.