Localized release of serotonin (5-hydroxytryptamine) by a fecal pellet regulates migrating motor complexes in murine colon.

Gastroenterology
Dante J HerediaTerence K Smith

Abstract

The colonic migrating motor complex (CMMC) is a motor pattern that regulates the movement of fecal matter through a rhythmic sequence of electrical activity and/or contractions along the large bowel. CMMCs have largely been studied in empty preparations; we investigated whether local reflexes generated by a fecal pellet modify the CMMC to initiate propulsive activity. Recordings of CMMCs were made from the isolated murine large bowel, with or without a fecal pellet. Transducers were placed along the colon to record muscle tension and propulsive force on the pellet and microelectrodes were used to record electrical activity from either side of a fecal pellet, circular muscle cells oral and anal of a pellet, and in colons without the mucosa. Spontaneous CMMCs propagated in both an oral or anal direction. When a pellet was inserted, CMMCs increased in frequency and propagated anally, exerting propulsive force on the pellet. The amplitude of slow waves increased during the CMMC. Localized mucosal stimulation/circumferential stretch evoked a CMMC, regardless of stimulus strength. The serotonin (5-hydroxytryptamine-3) receptor antagonist ondansetron reduced the amplitude of the CMMC, the propulsive force on the pellet, and the respon...Continue Reading

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Citations

Jun 26, 2013·Nature Reviews. Gastroenterology & Hepatology·Gary M Mawe, Jill M Hoffman
Sep 11, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dante J HerediaTerence K Smith
Dec 5, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Eamonn J DicksonTerence K Smith
Apr 24, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Eamonn J DicksonTerence K Smith
Oct 24, 2013·World Journal of Gastroenterology : WJG·Hiroki MoritaHiroyuki Kuwano
Feb 19, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B A Patel
Jun 16, 2010·The Journal of Physiology·Dante J HerediaTerence K Smith
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Aug 1, 2015·The Journal of Physiology·Terence K Smith, Michael D Gershon
Aug 1, 2015·The Journal of Physiology·Nick J SpencerDamien J Keating
Aug 1, 2015·The Journal of Physiology·Terence K Smith, Michael D Gershon
Apr 19, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·N J SpencerE A Beckett
May 29, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T OkamotoT K Smith
Feb 16, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P O BayguinovT K Smith
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Nov 5, 2014·Pflügers Archiv : European journal of physiology·Bruno Mazet
Mar 10, 2009·Gastroenterology·Hyun-Tai LeeTerence K Smith
Aug 11, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alexander D VincentJan D Huizinga
Apr 5, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Katharina BeckAndreas Friebe
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