PMID: 8592808Nov 1, 1995Paper

Localized retroperitoneal fibromatosis causing intestinal obstruction in a cynomolgus monkey (Macaca fascicularis)

Veterinary Pathology
J D Fikes, M G O'Sullivan

Abstract

Gross examination of a 24-month-old, male cynomolgus monkey (Macaca fascicularis) revealed obstruction of the ileum by a mass that entrapped and compressed the ileocecal junction. The mass was well circumscribed, firm, and white on cut surface. Histologically, the mass consisted of spindle-shaped cells arranged in interweaving bundles or as narrow cords and individual cells widely separated by dense collagen. A diagnosis of localized retroperitoneal fibromatosis was made based on the characteristic gross and microscopic findings and isolation of type D simian retrovirus, serotype-2, from spleen and mesenteric lymph node. Monkeys with localized retroperitoneal fibromatosis generally exhibit signs only of a palpable mass at the ileocecal junction and/or nonspecific diarrhea. This case represents an unusual presentation of localized retroperitoneal fibromatosis in which the lesion produced intestinal obstruction and death.

References

Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S A MilesT Kishimoto

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