PMID: 7145472Oct 1, 1982

Localized skin changes at the site of immunization with highly irradiated cercariae of Schistosoma mansoni are associated with enhanced resistance to a challenge infection

Parasitology
K L Miller, S R Smithers

Abstract

The level of immunity to a percutaneous cercarial challenge with Schistosoma mansoni was assayed 4-6 weeks after immunization of mice with highly irradiated (20 krad.) cercariae or schistosomula. When immunization and challenge occurred through the same skin site, resistance, particularly that which occurred in the skin, was greater than that observed when immunization and challenge occurred in different sites. The enhanced resistance is believed to be due to localized changes in the skin; 4 weeks after exposure to irradiated cercariae, abdominal skin is characterized by a thickened epidermis, changes in the ground substance and a cellular infiltration of the dermis. A convenient mouse model is described in which one or both ear pinnae are exposed to irradiated cercariae and a percutaneous challenge is given via the abdomen, thus eliminating the effects of local skin changes. In this model, the majority of the challenge infection which succumbs to the immune response appears to be killed in the skin.

References

Apr 1, 1979·Experimental Parasitology·S N Chen, R E Howells
Jan 1, 1978·The American Journal of Tropical Medicine and Hygiene·P MinardK D Murrell
Dec 1, 1974·Experimental Parasitology·F J Ramalho-PintoJ Pellegrino
Mar 1, 1972·International Journal for Parasitology·J A Clegg, S R Smithers
Sep 1, 1980·Molecular and Biochemical Parasitology·J F Dubremetz, C Dissous
Apr 1, 1982·Experimental Parasitology·D J McLaren, R N Incani
Sep 1, 1981·The American Journal of Tropical Medicine and Hygiene·M StekS S Clark
Sep 1, 1980·The American Journal of Tropical Medicine and Hygiene·S R Smithers, K L Miller

Citations

May 29, 1999·International Journal of Immunopharmacology·R Tarrab-HazdaiR Arnon
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·M A Smith, J A Clegg
Oct 1, 1985·Experimental Parasitology·A RuppelH J Diesfeld
Jan 1, 1989·Revista Do Instituto De Medicina Tropical De São Paulo·P M CoelhoC A Tavares
May 1, 1994·Revista Do Instituto De Medicina Tropical De São Paulo·K M TeixeiraS M Montenegro

Related Concepts

Epidermis
Granuloma
Variolation
Inflammation
Leukocytes
Mice, Inbred CBA
Mice, Inbred C57BL
Schistosoma mansoni
Katayama Fever
Skin

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