PMID: 11325449Apr 28, 2001Paper

Localized squamous-cell cancer of the esophagus: retrospective analysis of three treatment schedules

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
C DelcambreP Segol

Abstract

A retrospective study comparing chemotherapy and radiation, esophagectomy alone versus preoperative radiochemotherapy and surgery in localized squamous-cell esophageal carcinoma. Between 1989 and 1995, 139 patients (40 stage I, 77 stage IIA and 22 stage IIB according to the UICC 78 TNM classification) were treated in two different institutions. They were divided into three groups according to the treatment proposed: E group (treatment by esophagectomy; n = 30), RCT+E group (treatment by preoperative radiochemotherapy and esophagectomy; n = 46), RCT group (treatment by radiochemotherapy; n = 63). Factors like age, tumor localization and stage were similar in all groups. An intention to treat analysis was made. The E group showed no postoperative mortality, while in the RCT+E group, the surgery mortality was 12.8%. The mortality after RCT was 1.7%. After preoperative radiochemotherapy, a pathological complete response was observed in 25% of cases and the curative resection rate was higher (82% after RCT + E versus 60% after E). The 5-year survival difference between the three groups was not relevant (E group, 12.6%; RCT group, 25.8%; RCT + E group, 38.7%). The median survival was 29, 24 and 28.5 months, respectively. The event-fr...Continue Reading

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Citations

May 5, 2011·Cancer Biotherapy & Radiopharmaceuticals·Jingping YuSuping Sun
Jun 28, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Maria C López CarrizosaM M de Miguel
Jun 16, 2015·Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association·Ping WangZhongsheng Hua
Oct 26, 2007·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·B M SmithersD C Gotley
Sep 1, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C MarietteJ P Triboulet
Nov 19, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Arif Deniz OrduKhashayar Fakhrian

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