Localized therapeutic release via an amine-functionalized poly-p-xylene microfilm device

The Journal of Physical Chemistry. B
Erik RobinsonDean Ho

Abstract

Developing biocompatible polymeric platforms for drug delivery with enhanced localized activity represents a key facet of advanced interventional therapy. In this work, the drug-eluting potential of an amine-functionalized poly- p-xylene commonly known as Parylene A (4-amino(2,2)paracyclophane) was conducted with the microfilm device consisting of a primary base layer, drug film, and a secondary eluting layer presenting exposed amine groups which enhance the range of modifications that can be incorporated into the film. The murine macrophage cell line RAW 264.7 served as a cellular response to dexamethasone, a synthetic anti-inflammatory glucocorticoid and doxorubicin, an anticancer therapeutic. Decreased expression of NFkappa-B-mediated cytokines Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNFalpha), resultant DNA fragmentation, and spectroscopic analysis revealed the efficient and localized drug-eluting properties of the Parylene A polymeric bilayer.

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Citations

Feb 9, 2011·Biomedical Microdevices·John P SeymourDaryl R Kipke
Jul 30, 2009·Expert Opinion on Drug Delivery·Robert Lam, Dean Ho
Aug 31, 2012·Journal of Laboratory Automation·Han B Man, Dean Ho
Jan 30, 2017·Global Challenges·Amir Reza BagheriAndreas Greiner

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