Localized vaginal/uterine rhabdomyosarcoma-results of a pooled analysis from four international cooperative groups.

Pediatric Blood & Cancer
Veronique Minard-ColinInternational Society of Pediatric Oncology Sarcoma Committee, the Children's Oncology Group, the Italian Cooperative Soft T

Abstract

Vaginal/uterine rhabdomyosarcoma (VU RMS) is one of the most favorable RMS sites. To determine the optimal therapy, the experience of four cooperative groups (Children's Oncology Group [COG], International Society of Pediatric Oncology (SIOP) Malignant Mesenchymal Tumor Group [MMT], Italian Cooperative Soft Tissue Sarcoma Group [ICG], and European pediatric Soft tissue sarcoma Study Group [EpSSG]) was analyzed. From 1981 to 2009, 237 patients were identified. Median age (years) at diagnosis differed by tumor location; it was 1.9 for vagina (n = 160), 2.7 for uterus corpus (n = 26), and 13.5 for uterus cervix (n = 51). Twenty-eight percent of patients received radiation therapy (RT) as part of primary therapy (23% COG, 27% MMT, 46% ICG, and 42% EpSSG), with significant differences in the use of brachytherapy between the cooperative groups (23% COG, 76% MMT, 64% ICG, and 88% EpSSG). Ten-year event-free (EFS) and overall survival (OS) were 74% (95% CI, 67-79%) and 92% (95% CI, 88-96%), respectively. In univariate analysis, OS was inferior for patients with uterine RMS and for those with regional lymph node involvement. Although EFS was slightly lower in patients without initial RT (71% without RT vs. 81% with RT; P = 0.08), there ...Continue Reading

References

Nov 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F FlamantJ Lemerle
Sep 1, 1989·International Journal of Radiation Oncology, Biology, Physics·A P GerbauletD Chassagne
Mar 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W CristR Heyn
Dec 16, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F FlamantO Oberlin
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H MartelliM C Stevens
Jan 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·O OberlinUNKNOWN International Society of Paediatric Oncology Sarcoma Committee, Intergroup Rhabdomyosarcoma Study Group, Italian Cooperative
Jun 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W M CristS S Donaldson
Feb 25, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael C G StevensOdile Oberlin
Sep 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sheri L SpuntAllison L Hester
Aug 7, 2007·The Lancet Oncology·Nicolas Magné, Christine Haie-Meder
Mar 22, 2008·International Journal of Radiation Oncology, Biology, Physics·Nicolas MagnéChristine Haie-Meder
Oct 16, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Antonin LevyChristine Haie-Meder
Jun 2, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Dominic LeiserDamien C Weber
Jun 22, 2017·Archives of Gynecology and Obstetrics·Dimitrios NasioudisKevin Holcomb
Oct 14, 2017·Journal of the National Cancer Institute·Vivek VermaMark V Mishra

❮ Previous
Next ❯

Citations

Nov 9, 2018·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Rastislav DudičPeter Urdzík
Aug 17, 2018·Current Opinion in Obstetrics & Gynecology·Kathryn Stambough, Krista J Childress
Mar 7, 2021·Journal of Clinical Medicine·Christoph Wohlmuth, Iris Wohlmuth-Wieser
Jul 18, 2020·Journal of Pediatric Surgery·Daniel S RheeUNKNOWN American Pediatric Surgical Association Cancer Committee
Apr 6, 2021·Pediatric Blood & Cancer·Raphael L YechieliSarah S Donaldson
Apr 6, 2021·Pediatric Blood & Cancer·Dheerendra PrasadSuzanne Wolden
Dec 16, 2019·Journal of Pediatric and Adolescent Gynecology·Ozlem DuralD Ashley Hill
Aug 21, 2021·Seminars in Pediatric Surgery·Fuchs JWarmann Sw
Oct 3, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Iván A GonzálezLouis P Dehner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Odile OberlinInternational Society of Paediatric Oncology Sarcoma Committee, Intergroup Rhabdomyosarcoma Study Group, Italian Cooperative
© 2022 Meta ULC. All rights reserved