Localized vascular regression during limb morphogenesis in the chicken embryo: II. Morphological changes in the vasculature

The Anatomical Record
C H LatkerD C Beebe

Abstract

The regression of blood vessels in the distal wing bud of chicken embryos from stages 19 to 31 was examined by light and electron microscopy. The vessels were double-labelled by an injection of Monastral blue B (MB) to label the regressing endothelial cells, followed 6-48 hours later with an injection of India ink which marked the lumens of patent vessels. Prior to stage 26 the vessels contained only India ink since the endothelial cells were not phagocytic at this stage. Vessels at stage 26 or later were often double-labelled, with MB sequestered in the endothelial cell cytoplasm and India ink in the vessel lumens. After stage 27 cells not associated with lumens, but labelled with MB, were observed in areas undergoing vascular regression. Ultrastructural changes in the endothelial cells as the vessels regressed included formation of luminal and abluminal processes, long complex junctions, and vacuoles containing MB. In many involuting vessels the endothelial cells appeared normal even though the lumens were collapsed. Occasionally, isolated pyknotic cells were observed in regions that had been previously vascularized. At stage 31 cells in the developing cartilage had vacuoles containing MB. Our study suggests that blood vessel...Continue Reading

References

Sep 1, 1977·Biology of Reproduction·J D O'SheaW A Chamley
Mar 31, 1977·Acta Neuropathologica·J Mäkitie
Sep 1, 1975·Human Pathology·A Hirano, T Matsui
Jan 1, 1972·Histochemie. Histochemistry. Histochimie·H Korneliussen
May 1, 1972·Archives of Ophthalmology·R L Jack
Nov 4, 1966·Science·J W Saunders
Nov 1, 1968·Angiology·W E Stehbens, R M Ludatscher
May 1, 1982·Stain Technology·I JorisG Majno
Jan 1, 1984·Differentiation; Research in Biological Diversity·T Yamada, D S McDevitt
Jun 10, 1983·Science·R N Feinberg, D C Beebe
Feb 1, 1982·The Journal of Comparative Neurology·B L FinlayD R Sengelaub
Apr 1, 1965·Experimental and Molecular Pathology·R S COTRAN
Aug 1, 1962·Developmental Biology·J W SAUNDERS, M T GASSELING
Jan 1, 1951·Journal of Morphology·V HAMBURGER, H L HAMILTON
Feb 1, 1951·Biological Reviews of the Cambridge Philosophical Society·A GLUCKSMANN

❮ Previous
Next ❯

Citations

Jan 1, 1991·Anatomy and Embryology·R N FeinbergL Sweetman
May 11, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Natalia LandázuriW Robert Taylor
Feb 8, 2003·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Bela ErdösováVáclav Lichnovský
Sep 5, 2002·The Journal of Experimental Zoology·Martin KundrátKarel Smetana
Jun 3, 2004·Matrix Biology : Journal of the International Society for Matrix Biology·Doreen E Ashhurst
Jan 1, 1987·Differentiation; Research in Biological Diversity·R HallmannW Risau
Jul 29, 2003·Expert Opinion on Investigational Drugs·Ronald M Bukowski
Aug 9, 2002·Developmental Biology·Nathan D Lawson, Brant M Weinstein
Dec 18, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M Yin, M Pacifici
Nov 14, 2000·Circulation Research·S A FisherD Srivastava
Jan 1, 1994·The Anatomical Record·L Diaz-FloresM Perez
Jan 30, 2008·Birth Defects Research. Part C, Embryo Today : Reviews·Young Ryun Cha, Brant M Weinstein
Apr 19, 2007·Genesis : the Journal of Genetics and Development·Kimberly E Inman, Karen M Downs
May 1, 1997·Journal of Orthopaedic Trauma·C T Brighton, R M Hunt
Apr 1, 1996·Die Naturwissenschaften·J Wilting, B Christ
Oct 1, 1994·The American Journal of Physiology·C H WendtD H Ingbar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.