Localizing Memory Functions in Brain Tumor Patients: Anatomical Hotspots over 260 Patients

World Neurosurgery
Fabio CampanellaMiran Skrap

Abstract

Memory complaints are common in patients after brain tumor, but is difficult to map memory functions during awake surgery, to preserve them. Thus we analyzed one of the largest data sets on clinical, surgical, and anatomical correlates of memory in patients with brain tumor to date, providing anatomical hotspots for short and long-term memory functions. A total of 260 patients with brain tumor (130 high-grade gliomas; 76 low-grade gliomas [LGG]; 54 meningiomas) were tested on 2 commonly used short-term memory (Digit Span Forward and Corsi Spatial Span) and 2 long-term memory tasks (Narrative Memory and Delayed Recall of Rey Figure). Patients were evaluated before and immediately after surgery and (for LGG) after 4 months and data analyzed by means of analysis of covariance and the voxel-based lesion-symptom mapping technique. As expected, patients with high-grade gliomas were already impaired before surgery, whereas patients with meningioma were largely unimpaired. Patients with LGG were unimpaired before surgery, but showed significant performance drop immediately after, with good recovery within few months. Voxel-based lesion-symptom mapping analyses identified specific anatomical correlates for verbal memory tasks, whereas v...Continue Reading

Citations

Jan 22, 2021·Journal of Cognitive Neuroscience·Sandra ArbulaAntonino Vallesi
Feb 2, 2021·Neuropsychologia·Fabio CampanellaMiran Skrap
Aug 11, 2021·Journal of Cognitive Neuroscience·Sandra ArbulaAntonino Vallesi

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