Localizing organomercury uptake and accumulation in zebrafish larvae at the tissue and cellular level.

Proceedings of the National Academy of Sciences of the United States of America
Malgorzata KorbasGraham N George

Abstract

Using synchrotron x-ray fluorescence mapping, we have examined the uptake and localization of organic mercury in zebrafish larvae. Strikingly, the greatest accumulation of methyl and ethyl mercury compounds was highly localized in the rapidly dividing lens epithelium, with lower levels going to brain, optic nerve, and various other organs. The data suggest that the reported impairment of visual processes by mercury may arise not only from previously reported neurological effects, but also from direct effects on the ocular tissue. This novel approach is a powerful tool for directly investigating the molecular toxicology of heavy metals, and should be equally applicable to the study of a wide range of elements in developing embryos.

References

Jun 1, 1990·Experimental Eye Research·V N Reddy
Jan 1, 1987·Experimental Eye Research·G DuValP J Bentley
Jul 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C B KimmelT F Schilling
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·I J PickeringG N George
Apr 30, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gi-Wook HwangAkira Naganuma
May 14, 2003·Neurochemistry International·Hong QuUrsula Sonnewald
Jul 2, 2003·Neurotoxicity Research·Coral SanfeliuEduard Rodríguez-Farré
Aug 30, 2003·Science·Hugh H HarrisGraham N George
Aug 4, 2004·Neurotoxicology·Evelin VicenteCarlos-Alberto Gonçalves
Aug 11, 2004·Progress in Biophysics and Molecular Biology·Hans BloemendalAnnette Tardieu
Aug 18, 2004·Chemical Research in Toxicology·Graham N GeorgeIngrid J Pickering
Feb 11, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Adrian J HillRichard E Peterson
Jun 20, 2006·Chemical Research in Toxicology·Ruth E HoffmeyerGraham N George
Sep 16, 2006·Critical Reviews in Toxicology·Thomas W Clarkson, Laszlo Magos
Sep 19, 2006·Cutaneous and Ocular Toxicology·Ahmed M El-SherbeenyJames E Smith
Oct 24, 2006·The British Journal of Ophthalmology·M SaldanaO Backhouse
Oct 26, 2006·Journal of the American Chemical Society·Sung-Kyun KoInjae Shin
Apr 24, 2007·Neurotoxicity Research·Carolina JohanssonSandra Ceccatelli
May 1, 2007·Experimental Eye Research·Ralf DahmGijs F J M Vrensen
Aug 1, 2007·Angewandte Chemie·Sungho YoonChristopher J Chang
Oct 2, 2007·Physiology & Behavior·Daniel N WeberMichael J Carvan
Feb 16, 2008·Science·Brian D CorbinEric P Skaar
Mar 14, 2008·Chembiochem : a European Journal of Chemical Biology·Bo TangLi Guo An

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Citations

Dec 15, 2010·ACS Chemical Neuroscience·Malgorzata KorbasGraham N George
Sep 24, 2009·Chemical Reviews·Reagan McRaeChristoph J Fahrni
Nov 16, 2010·Chemical Research in Toxicology·Vicky Mah, Farideh Jalilehvand
May 10, 2011·Chemical Communications : Chem Comm·Mi Eun JunKyo Han Ahn
Feb 26, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lixin YangUwe Strähle
May 28, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lisa PrinceMatthew Dearborn Rand
Mar 13, 2010·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Graham N GeorgeIngrid J Pickering
Jun 1, 2010·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Malgorzata KorbasGraham N George
May 23, 2009·Toxicology·Richard R Chapleau, Martin Sagermann
Feb 13, 2013·Journal of Applied Toxicology : JAT·José G DóreaJoão B T Rocha
Jul 14, 2012·Magnetic Resonance Imaging·Weili ZhengHelen Nichol
Jul 25, 2014·The Science of the Total Environment·Patrícia PereiraMário Pacheco
Jan 22, 2015·Environmental Science & Technology·Sanjukta ChoudhuryIngrid J Pickering
Oct 12, 2016·Nihon eiseigaku zasshi. Japanese journal of hygiene·Yuta Komoike, Masato Matsuoka
Aug 1, 2015·Journal of Inorganic Biochemistry·Tracy C MacDonaldPatrick H Krone
Jan 20, 2016·Metallomics : Integrated Biometal Science·N V DolgovaI J Pickering
Jul 17, 2015·Metallomics : Integrated Biometal Science·Tracy C MacDonaldIngrid J Pickering
Jan 26, 2018·The Journal of Experimental Biology·Carlos Tejeda-GuzmánFanis Missirlis
Sep 5, 2018·Journal of Synchrotron Radiation·Nicholas P EdwardsUwe Bergmann
Oct 30, 2009·Organic & Biomolecular Chemistry·Young-Keun YangJinsung Tae
Aug 8, 2019·PloS One·Roger PamphlettSvetlana Cherepanoff
Aug 21, 2020·Environmental Science and Pollution Research International·Ashif IqubalSyed Ehtaishamul Haque
Jan 18, 2011·Chemical Society Reviews·Sung-Kyun KoInjae Shin
Jan 29, 2019·Metallomics : Integrated Biometal Science·Natalia V DolgovaIngrid J Pickering
Apr 26, 2016·Metallomics : Integrated Biometal Science·Tracy C MacDonaldGraham N George
Mar 3, 2021·ACS Nano·Carlos Sanchez-CanoWolfgang J Parak
Jun 26, 2020·Aquatic Toxicology·Lianguo Chen
Mar 29, 2019·The Science of the Total Environment·Ana I CatarinoTheodore B Henry

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