Locally acting ACE-083 increases muscle volume in healthy volunteers

Muscle & Nerve
Chad E GlasserKenneth M Attie

Abstract

ACE-083 is a locally acting follistatin-based therapeutic that binds myostatin and other muscle regulators and has been shown to increase muscle mass and force in neuromuscular disease mouse models. This first-in-human study examined these effects. In this phase 1, randomized, double-blind, placebo-controlled, dose-ranging study in healthy postmenopausal women, ACE-083 (50-200 mg) or placebo was administered unilaterally into rectus femoris (RF) or tibialis anterior (TA) muscles as 1 or 2 doses 3 weeks apart. Fifty-eight postmenopausal women were enrolled, 42 ACE-083 and 16 placebo. No serious adverse events (AE), dose-limiting toxicities, or discontinuations resulting from AEs occurred. Maximum (mean ± SD) increases in RF and TA muscle volume were 14.5% ± 4.5% and 8.9% ± 4.7%, respectively. No significant changes in mean muscle strength were observed. ACE-083 was well tolerated and resulted in significant targeted muscle growth. ACE-083 may have the potential to increase muscle mass in a wide range of neuromuscular disorders. Muscle Nerve 57: 921-926, 2018.

Associated Clinical Trials

References

Mar 13, 2008·Annals of Neurology·Kathryn R WagnerJerry R Mendell
Feb 12, 2009·Muscle & Nerve·Louise R Rodino-KlapacJerry R Mendell
Nov 9, 2014·Neurology·Anthony A AmatoSteven A Greenberg
Oct 31, 2015·The Lancet. Diabetes & Endocrinology·Clemens BeckerUNKNOWN STEADY Group
Apr 30, 2017·Nature Communications·Esther LatresJesper Gromada

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Citations

Oct 23, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Bryan C Jiang, Dennis T Villareal
Dec 20, 2018·The Journal of Pharmacology and Experimental Therapeutics·Roselyne CastonguayRavi Kumar
Dec 4, 2019·Continuum : Lifelong Learning in Neurology·Kathryn R Wagner
Aug 17, 2020·Current Opinion in Neurology·Maike F Dohrn, Mario Saporta
Sep 3, 2020·Journal of Nephrology·Alice SabatinoCarla Maria Avesani
Aug 4, 2020·Annals of Geriatric Medicine and Research·Ju Yeon Kwak, Ki-Sun Kwon
Jul 25, 2019·International Journal of Molecular Sciences·Jonathan MorenaJ Chad Hoyle
Sep 11, 2020·Journal of Bone Metabolism·Joonho Suh, Yun-Sil Lee
Jan 27, 2021·Scientific Reports·Hiroyasu MuramatsuJunichi Nezu
Oct 24, 2020·Trends in Molecular Medicine·Justin CohenAngela Lek
Dec 26, 2019·Bioorganic & Medicinal Chemistry Letters·Mariko SaitohYoshio Hayashi
Oct 25, 2020·International Journal of Molecular Sciences·Tai-Heng ChenYung-Hao Tseng
Jun 6, 2020·European Journal of Translational Myology·Danielle VaughanKetan Patel
May 3, 2021·Cytokine & Growth Factor Reviews·Andreas Lodberg
May 7, 2021·Bioorganic & Medicinal Chemistry·Tomo AsariKentaro Takayama
May 26, 2021·Expert Review of Neurotherapeutics·Chiara PisciottaDavide Pareyson
Jun 22, 2019·ACS Medicinal Chemistry Letters·Kentaro TakayamaYoshio Hayashi
Sep 15, 2021·Endocrine Reviews·Buel D Rodgers, Christopher W Ward

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Clinical Trials Mentioned

NCT02257489
NCT02927080
NCT03124459

Software Mentioned

VirtualScopics
qPharmetra

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