PMID: 3759583Sep 1, 1986Paper

Locally advanced breast carcinoma: results with combined regional therapy

International Journal of Radiation Oncology, Biology, Physics
L M ToonkelC B Wallach

Abstract

To define optimal regional treatment as initial management of locally advanced (Stage III & IV) breast cancer, 509 patients treated from 1966-1982 were reviewed. All patients received comprehensive postoperative irradiation of the peripheral lymphatics and chest wall, following surgical procedures varying from incisional biopsy to classical radical mastectomy. Patients were followed from 1 to over 16 years. The survival rate at 5 and 10 years for the entire series is 41% and 26%. Fifty-eight patients having radical surgery for T3 tumors and subsequently found to have negative axillary lymph nodes showed the highest rates of survival, 72% at 5 years and 57% at 10 years. This was significantly better (p less than .01) than patients with T3N+ disease, (5 year survival 44%; 10 year, 29%) and T4N+ disease (44%, 39%). Four hundred seventy patients with non-inflammatory carcinoma and no supraclavicular metastases were considered technically resectable. Three hundred eighty-one of these patients underwent a definitive surgical procedure removing all gross cancer prior to irradiation and, as expected, showed higher rates of local disease control than patients having lesser surgery (79% versus 45%, p less than .01). These patients also s...Continue Reading

References

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Citations

Mar 17, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Tamara ShenkierUNKNOWN Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer
Mar 28, 2006·Future Oncology·Charles H Yang, Massimo Cristofanilli
Sep 13, 2011·The Breast Journal·Shannon M MacdonaldBruce G Haffty
Apr 3, 2007·International Journal of Radiation Oncology, Biology, Physics·Verity AhernNicholas Wilcken
Dec 6, 2003·The Oncologist·Sharon H Giordano
Mar 1, 1992·Journal of Surgical Oncology·S T BrowerJ Camunas

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