PMID: 8606319Feb 1, 1996Paper

Locally advanced non-small cell lung cancer: do we know the questions? A survey of randomized trials from 1966-1993

Journal of Clinical Epidemiology
M D Brundage, W J Mackillop

Abstract

Substantial lack of consensus exists regarding the appropriate management of patients with locally advanced non-small cell lung cancer (NSCLC). The purpose of the present study was to investigate why published clinical trials have not resolved this uncertainty, and to examine the potential of current randomized studies to resolve the major controversies regarding the treatment of locally advanced NSCLC. A literature search identified papers addressing the therapy of locally advanced NSCLC published in the English language from January 1966 through May 1993. The treatment modalities studied in these trials were recorded. The CD-ROM Physician Data Query database was used to identify ongoing studies in NSCLC. For phase III trials in stage III NSCLC, the treatment modalities, eligibility criteria, outcome measures, and statistical considerations were recorded. A total of 164 reports of phase III trials were identified, representing 11% of the 1516 publications meeting search criteria. A wide range of comparisons have been reported; the number of study arms, the number of different modalities employed as control arms, and the number of modalities employed as investigational arms increased over time. Eighteen active phase III protoco...Continue Reading

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