Locally aggressive and multifocal phosphaturic mesenchymal tumors: two unusual cases of tumor-induced osteomalacia

Skeletal Radiology
Meghan HigleyErik Foss

Abstract

Tumor-induced osteomalacia (TIO) has long been recognized as a clinical paraneoplastic syndrome. The identification of a unique histopathologic entity, the phosphaturic mesenchymal tumor (PMT), as a distinct etiology for TIO has been a more recent discovery. The majority of published cases describe a solitary, non-aggressive appearing soft tissue or osseous lesions in patients with osteomalacia; aggressive appearing or multifocal lesions appear to be exceedingly rare. These tumors characteristically secrete fibroblast growth factor 23 (FGF23). Elevated serum levels of FGF23 result in phosphate wasting and osteomalacia. In the majority of cases, laboratory abnormalities and clinical signs and symptoms of osteomalacia precede identification of the causative lesion by years. Following diagnosis, complete resection with wide margins to prevent local recurrence is most often curative. Imaging characteristics of PMT are diverse and remain incompletely defined, as the majority of previous publications are outside of the radiologic literature. We present multiple imaging modalities in two cases of patients with debilitating osteomalacia and unusual appearing PMTs: one with a locally aggressive lesion leading to pathologic fracture, the...Continue Reading

References

Aug 1, 1994·Journal of Korean Medical Science·Y K ParkS F Hodgson
Aug 1, 1996·AJR. American Journal of Roentgenology·N A AvilaJ L Doppman
May 4, 2000·Skeletal Radiology·M Sundaram, E F McCarthy
May 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·T ShimadaT Yamashita
Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·Yasuhiro TakeuchiToshiro Fujita
Jan 7, 2009·Archives of Orthopaedic and Trauma Surgery·Roberto SeijasManuel Pérez-Dominguez
Apr 15, 2011·Endocrine-related Cancer·William H ChongMichael T Collins
May 26, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Panagiota AndreopoulouMichael T Collins
Jan 9, 2013·The Journal of Clinical Endocrinology and Metabolism·Roderick J Clifton-BlighRodney J Hicks
Mar 12, 2013·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Katsuyuki NakanishiNoriyuki Tomiyama
Oct 15, 2013·Histopathology·D Chas Mangham, Lars-Gunnar Kindblom
Jan 10, 2014·Skeletal Radiology·Monica C KoplasMurali Sundaram
Jun 25, 2014·Oncology Letters·Tokimitsu MorimotoHideki Yoshikawa
Jul 8, 2014·Clinical Nuclear Medicine·Kanhaiyalal AgrawalAnil Bhansali
Apr 9, 2015·Clinical Kidney Journal·Ambika AmbleePeter Hart
Apr 23, 2015·Current Rheumatology Reports·Anke H HautmannMartin Fleck
May 23, 2015·Clinical Endocrinology·Nisha BhavaniHarish Kumar

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Citations

Feb 7, 2019·Endocrine Connections·Rimesh PalVikas Agashe
May 21, 2017·Biomédica : revista del Instituto Nacional de Salud·Diana L Franco, Leslie Thomas
Nov 7, 2017·Case Reports in Rheumatology·Sara BeygiTarun S Sharma
Jul 14, 2017·Nature Reviews. Disease Primers·Salvatore MinisolaMichael T Collins
Feb 15, 2017·BMC Musculoskeletal Disorders·Ryuta AraiNorimasa Iwasaki
Dec 9, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Zhenzhen ZhuWei Lv

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