Locally controlled delivery of TNFα antibody from a novel glucose-sensitive scaffold enhances alveolar bone healing in diabetic conditions

Journal of Controlled Release : Official Journal of the Controlled Release Society
Qi WangChongyun Bao

Abstract

Diabetic patients are often accompanied with severe alveolar bone destruction and an increased local TNFα level. Bone repair is a major challenge in those with poor glycemic control. Herein, we report a glucose-sensitive TNFα-antibody-delivery system based on quaternized chitosan and collagen for local long-term control of inflammation and improving osteogenesis in diabetes. We demonstrated that the glucose-sensitive delivery system was a honeycomb-shaped scaffold with pores suitable for bone regeneration. It was capable of attenuating inflammatory response of bone marrow stromal cells under the condition of hyperglucose and TNFα. Additionally, a special diabetic rat model with fluctuation of blood glucose level was established to investigate biological effects of the scaffold. Our results showed that this TNFα-antibody-delivery strategy effectively reduced inflammation by decreasing expression of local TNFα and inflammatory factors. More importantly, with the enhancement of osteogenesis-associated proteins, promoted alveolar bone healing was achieved in the diabetic rat model. The data indicate that such a delivery system possibly provides a potential therapeutic strategy for diabetic patients with severe alveolar bone defects.

References

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Citations

Jan 19, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mario Moisés AlvarezAli Khademhosseini
Mar 10, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fang YangNing Gu
Sep 30, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Satheesh ElangovanAliasger K Salem
Jan 26, 2017·Acta Biomaterialia·Ziad JulierMikaël M Martino
Oct 31, 2019·Biomaterials Science·Abdollah Zakeri SiavashaniMarkus Rottmar
May 31, 2019·Journal of Orthopaedic Surgery and Research·Hao LiWei Li
Jul 30, 2017·Journal of Functional Biomaterials·Fabiola Vaca-CornejoJudith M Dueñas Jiménez
Dec 28, 2017·ACS Applied Materials & Interfaces·Zhiai HuXiaohua Liu

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