Locally stable brain states predict suppression of epileptic activity by enhanced cognitive effort

NeuroImage. Clinical
Sarah F MuldoonDanielle S Bassett

Abstract

Cognitive effort is known to play a role in healthy brain state organization, but little is known about its effects on pathological brain dynamics. When cortical stimulation is used to map functional brain areas prior to surgery, a common unwanted side effect is the appearance of afterdischarges (ADs), epileptiform and potentially epileptogenic discharges that can progress to a clinical seizure. It is therefore desirable to suppress this activity. Here, we analyze electrocorticography recordings from 15 patients with epilepsy. We show that a cognitive intervention in the form of asking an arithmetic question can be effective in suppressing ADs, but that its effectiveness is dependent upon the brain state at the time of intervention. By applying novel techniques from network analysis to quantify brain states, we find that the spatial organization of ADs with respect to coherent brain regions relates to the success of the cognitive intervention: if ADs are mainly localized within a single stable brain region, a cognitive intervention is likely to suppress the ADs. These findings show that cognitive effort is a useful tactic to modify unstable pathological activity associated with epilepsy, and suggest that the success of therapeu...Continue Reading

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Citations

Oct 11, 2019·Brain : a Journal of Neurology·Lohith G KiniBrian Litt
Nov 17, 2020·Network Neuroscience·Pragya SrivastavaDanielle S Bassett
Feb 9, 2021·Frontiers in Human Neuroscience·Ronald P LesserYusuke Yamamoto

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Methods Mentioned

BETA
surgical resection

Software Mentioned

MATLAB

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