PMID: 11902123Mar 21, 2002Paper

Locally synthesized angiotensin modulates pineal melatonin generation

Journal of Neurochemistry
Ovidiu BaltatuJosé Cipolla-Neto

Abstract

We aimed to study the mechanisms and the significance of the influence exerted by the renin-angiotensin system (RAS) on the pineal melatonin production. Pineal melatonin and other indoles were determined by HPLC with electrochemical detection after angiotensin AT1-receptor blockade with Losartan in vivo or in cultured glands. N-acetyltransferase (NAT) activity was radiometricaly measured. To test the in vivo relevance of the local RAS, pineal melatonin and its indole precursors were determined in transgenic rats with inhibited production of angiotensinogen exclusively in astrocytes, TGR(ASrAOGEN). Tryptophan hydroxylase (TPH) and NAT mRNA levels were determined by real-time RT-PCR. Pineal melatonin content was significantly decreased by AT1-receptor blockade in vivo, in cultured glands and in TGR(ASrAOGEN) (35%, 32.4% and 17.5% from control, respectively). Losartan produced a significant decrease of pineal 5-hydroxytryptophan, serotonin, 5-hydroxyindole acetic acid and N-acetylserotonin in pineal cultures. Also, the pineal content of the precursor indoles in TGR(ASrAOGEN) rats was significantly lowered. The reduction of 5-hydroxytryptophan levels by 33-75% in both in vivo and in vitro studies suggests a decreased activity of TP...Continue Reading

Citations

Jul 17, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Elio Agostoni, Angelo Aliprandi
May 5, 2005·Brain Research·Jörg-Peter VoigtHeidrun Fink
Jun 4, 2011·Addiction Biology·Rafael PeresJosé Cipolla-Neto
Jan 30, 2004·Annual Review of Medicine·Avi Ashkenazi, Stephen D Silberstein
Apr 25, 2012·Indian Journal of Pharmacology·Ruchika Nandha, Harpal Singh
Apr 30, 2014·Revista Española De Cardiología·Alberto Dominguez-Rodriguez, Pedro Abreu-Gonzalez
Feb 22, 2011·Peptides·Ovidiu C BaltatuMichael Bader
Jul 14, 2010·Pharmacology, Biochemistry, and Behavior·J-P VoigtA Rex
Dec 1, 2007·Life Sciences·Rodrigo Antonio Peliciari GarciaJosé Cipolla-Neto
Feb 1, 2013·International Journal of Hypertension·Luciana A CamposOvidiu C Baltatu
Aug 13, 2013·BioMed Research International·Rodrigo Antonio Peliciari-GarciaCarla Roberta de Oliveira Carvalho
Jul 31, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Anjana Bali, Amteshwar Singh Jaggi
Jun 1, 2018·Journal of Pineal Research·Natalia Jorgelina PradoWalter Manucha
Sep 7, 2005·Cell Biochemistry and Function·Solange C AfecheJosé Cipolla-Neto
Sep 15, 2018·Endocrine Reviews·José Cipolla-Neto, Fernanda Gaspar do Amaral
Dec 31, 2002·JAMA : the Journal of the American Medical Association·Erling TronvikGunnar Bovim
May 30, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Luciana A CamposOvidiu C Baltatu
May 11, 2018·Current Hypertension Reports·Natalia Jorgelina PradoEmiliano Raúl Diez
Dec 13, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Luciana A CamposOvidiu C Baltatu
Aug 10, 2017·Cellular and Molecular Life Sciences : CMLS·Ovidiu C BaltatuJose Cipolla-Neto
Jan 6, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Naro OhashiShinsuke Isobe
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmet Ozer SehirliNedime Serakinci
Jan 11, 2022·Pharmacology Research & Perspectives·Keming HuangJian Feng

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