Location and restoration of function after cerebellar tumor removal-a longitudinal study of children and adolescents.

The Cerebellum
M KüperDagmar Timmann

Abstract

Sequelae in children following cerebellar tumor removal surgery are well defined, and predictors for poor recovery include lesions of the cerebellar nuclei and the inferior vermis. Dynamic reorganization is thought to promote functional recovery in particular within the first year after surgery. Yet, the time course and mechanisms of recovery within this critical time frame are elusive and longitudinal studies are missing. Thus, a group of children and adolescents (n = 12, range 6-17 years) were followed longitudinally after cerebellar surgery and compared to age- and gender-matched controls (n = 11). Patients were examined (1) within the first days, (2) 3 months, and (3) 1 year after surgery. Each time behavioral tests of balance and upper limb motor function, ataxia rating, and a MRI scan were performed. Data were used for subsequent lesion-symptom mapping of cerebellar function. Behavioral improvements continued beyond 3 months, but were not complete in all patients after 1 year. At that time, remaining deficits were mild. Within the first 3 months, cerebellar lesion volumes were notably reduced by vanishing edema. Reduction in edema affecting the deep cerebellar nuclei but not reduction of total cerebellar lesion volume was...Continue Reading

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Citations

Nov 13, 2015·Pediatric Hematology and Oncology·Regine Söntgerath, Katharina Eckert
Mar 10, 2016·Brain & Development·Masahiro NishiyamaKazumoto Iijima
Mar 10, 2016·Journal of the International Neuropsychological Society : JINS·Alyssa S AilionBruce Crosson
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Jun 22, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Philippe F PaquierCoriene E Catsman-Berrevoets
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Sep 22, 2020·Brain Communications·Pierre-Aurélien BeuriatMichel Desmurget
Jan 28, 2020·Seminars in Oncology Nursing·Lynn TannerJessica Sparrow
Jul 8, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·H HartleyR Kumar
Aug 7, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Frederik GrossePablo Hernáiz Driever

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