Location-dependent correlation between tissue structure and the mechanical behaviour of the urinary bladder

Acta Biomaterialia
Enrique Morales-OrcajoMarkus Böl

Abstract

The mechanical properties of the urinary bladder wall are important to understand its filling-voiding cycle in health and disease. However, much remains unknown about its mechanical properties, especially regarding regional heterogeneities and wall microstructure. The present study aimed to assess the regional differences in the mechanical properties and microstructure of the urinary bladder wall. Ninety (n=90) samples of porcine urinary bladder wall (ten samples from nine different locations) were mechanically and histologically analysed. Half of the samples (n=45) were equibiaxially tested within physiological conditions, and the other half, matching the sample location of the mechanical tests, was frozen, cryosectioned, and stained with Picro-Sirius red to differentiate smooth muscle cells, extracellular matrix, and fat. The bladder wall shows a non-linear stress-stretch relationship with hysteresis and softening effects. Regional differences were found in the mechanical response and in the microstructure. The trigone region presents higher peak stresses and thinner muscularis layer compared to the rest of the bladder. Furthermore, the ventral side of the bladder presents anisotropic characteristics, whereas the dorsal side ...Continue Reading

Citations

Feb 23, 2019·Frontiers in Physiology·Mischa BorsdorfTobias Siebert
Dec 29, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Robin TrostorfMarkus Böl
Feb 13, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Ramachandra KuraviAlexander E Ehret
Apr 27, 2021·Pflügers Archiv : European journal of physiology·Mischa BorsdorfTobias Siebert
Jun 14, 2021·Acta Biomaterialia·Sindhu NagarajaMarkus Böl

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