Location, Location, Location: Alterations in the Functional Topography of Face- but not Object- or Place-Related Cortex in Adolescents with Autism.

Frontiers in Human Neuroscience
K Suzanne ScherfMarlene Behrmann

Abstract

In autism, impairments in face processing are a relatively recent discovery, but have quickly become a widely accepted aspect of the behavioral profile. Only a handful of studies have investigated potential atypicalities in autism in the development of the neural substrates mediating face processing. High-functioning individuals with autism (HFA) and matched typically developing (TD) controls watched dynamic movie vignettes of faces, common objects, buildings, and scenes of navigation while undergoing an fMRI scan. With these data, we mapped the functional topography of category-selective activation for faces bilaterally in the fusiform gyrus, occipital face area, and posterior superior temporal sulcus. Additionally, we mapped category-selective activation for objects in the lateral occipital area and for places in the parahippocampal place area in the two groups. Our findings do not indicate a generalized disruption in the development of the entire ventral visual pathway in autism. Instead, our results suggest that the functional topography of face-related cortex is selectively disrupted in autism and that this alteration is present in early adolescence. Furthermore, for those HFA adolescents who do exhibit face-selective acti...Continue Reading

Citations

Jan 8, 2011·Neurotoxicity Research·Aysenil BelgerFranc C L Donkers
Jan 1, 2012·Microbial Ecology in Health and Disease·Kenneth HugdahlLars Ersland
Jul 16, 2014·Brain and Cognition·Kirsten O'HearnBeatriz Luna
Apr 16, 2015·Developmental Science·Elisabeth M WhyteK Suzanne Scherf
Jan 4, 2012·Neuroscience and Biobehavioral Reviews·Sarah WeigeltNancy Kanwisher
Dec 7, 2010·Brain Research·Kimberly A StiglerChristopher J McDougle
Jul 31, 2013·Autism Research : Official Journal of the International Society for Autism Research·Leo ArkushDavid H Skuse
Apr 12, 2011·Developmental Science·Kirsten O'HearnBarbara Landau
Oct 15, 2013·Autism Research : Official Journal of the International Society for Autism Research·Robin LaycockSheila Gillard Crewther
Dec 17, 2014·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Gizelle AnzuresMark H Johnson
Nov 2, 2013·NeuroImage. Clinical·Xiong JiangMaximilian Riesenhuber
Mar 7, 2013·Neuropsychologia·Geneviève CharbonneauOlivier Collignon
Apr 26, 2011·NeuroImage·Marc N CoutancheRobert T Schultz
May 17, 2015·Trends in Cognitive Sciences·Ilan DinsteinMarlene Behrmann
Apr 2, 2015·Neuropsychologia·Jason S Nomi, Lucina Q Uddin
Nov 28, 2012·PloS One·György A HomolaAndreas J Bartsch
May 1, 2013·PloS One·John A PylesMichael J Tarr
Dec 17, 2017·Scientific Reports·Silke KlamerThomas Ethofer
Jun 28, 2019·European Journal of Pediatrics·Shahar SheferLidia V Gabis
Aug 22, 2017·Frontiers in Human Neuroscience·Wataru SatoMotomi Toichi
Dec 22, 2019·Genes·Andrew G McKechanieAndrew C Stanfield

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

© 2021 Meta ULC. All rights reserved