Location, location, location: Beneficial effects of autologous fat transplantation.

Scientific Reports
Sarang N SatoorAnandwardhan A Hardikar

Abstract

Visceral adiposity is a risk factor for cardiovascular disorders, type 2 diabetes mellitus (T2D) and associated metabolic diseases. Sub-cutaneous fat is believed to be intrinsically different from visceral fat. To understand molecular mechanisms involved in metabolic advantages of fat transplantation, we studied a rat model of diet-induced adiposity. Adipokine genes (Adiponectin, Leptin, Resistin and Visfatin) were expressed at 10,000 to a million-fold lower in visceral fat depot as compared to peripheral (thigh/chest) fat depots. Interestingly, autologous transplantation of visceral fat to subcutaneous sites resulted in increased gene transcript abundance in the grafts by 3 weeks post-transplantation, indicating the impact of local (residence) factors influencing epigenetic memory. We show here that active transcriptional state of adipokine genes is linked with glucose mediated recruitment of enzymes that regulate histone methylation. Adipose depots have "residence memory" and autologous transplantation of visceral fat to sub-cutaneous sites offers metabolic advantage.

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May 24, 2012·Nature Communications·Mingzhou LiRuiqiang Li
May 28, 2013·Lipids in Health and Disease·Chaowei ZhouXuewei Li
Jul 28, 2012·International Journal of Molecular Sciences·Mingzhou LiXuewei Li
Jun 22, 2012·International Journal of Biological Sciences·Mingzhou LiXuewei Li
Nov 6, 2014·Hormone Molecular Biology and Clinical Investigation·Andrea BoothMichelle Foster
Mar 9, 2018·The Journal of Experimental Biology·Theresa SchoettlSiegfried Ussar
May 18, 2013·Journal of Applied Physiology·Takeshi HashimotoMotoyuki Iemitsu
Sep 21, 2013·Development·Daniel C BerryJonathan M Graff
Jan 6, 2022·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Agnieszka MikłoszAdrian Chabowski

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Methods Mentioned

BETA
transgenic
PCR
immunoprecipitation
biopsy
X-ray
ELISAs

Software Mentioned

Primerquest

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