PMID: 15353426Sep 9, 2004Paper

Location of adenomas missed by optical colonoscopy

Annals of Internal Medicine
Perry J PickhardtWilliam R Schindler

Abstract

Previous estimates of the adenoma miss rate with optical colonoscopy (OC) are hindered by the use of OC as its own reference standard. To evaluate the frequency and characteristics of colorectal neoplasms that are missed prospectively on OC by using virtual colonoscopy (VC) as a separate reference standard. Prospective, multicenter screening trial. 3 medical centers. 1233 asymptomatic adults who underwent same-day VC and OC. Colorectal neoplasms (adenomatous polyps) missed at OC before VC results were unblinded. Fourteen (93.3%) of 15 nonrectal neoplasms were located on a fold; 10 (71.4%) of these were located on the backside of a fold. Five (83.3%) of 6 rectal lesions were located within 10 cm of the anal verge. Estimation of the OC miss rate depended on polyp detection on both VC and second-look OC and therefore underestimates the true OC miss rate, particularly for smaller polyps. Most clinically significant adenomas missed prospectively on OC are located behind a fold or near the anal verge. The 12% OC miss rate for large adenomas (>or=10 mm) when state-of-the-art 3-dimensional VC is used as a separate reference standard is increased from the previous 0% to 6% estimates derived by using OC as its own reference standard.

Associated Clinical Trials

Citations

Mar 26, 2008·Archives of Internal Medicine·Harvey J MurffWilliam J Blot
Aug 14, 2010·Diseases of the Colon and Rectum·C HassanJ R Choi
Apr 28, 2012·Abdominal Imaging·Perry J Pickhardt
Jan 14, 2010·European Radiology·Perry J PickhardtDavid H Kim
Apr 23, 2010·Digestive Diseases and Sciences·A WangG M Eisen
Jun 18, 2011·Digestive Diseases and Sciences·Amanpal SinghJames S Goodwin
Nov 13, 2013·Current Gastroenterology Reports·Lukejohn W DayJames Allison
Oct 17, 2006·Current Oncology Reports·James E Allison, Michael Lawson
Jan 1, 2007·Journal of Gastrointestinal Cancer·Catherine T Frenette, Williamson B Strum
Apr 10, 2007·AORN Journal·Kathleen D Pagana
Mar 11, 2005·Gastrointestinal Endoscopy·David Lieberman
Dec 15, 2012·Clinical and Translational Gastroenterology·M N HernandezL E Fleming
Oct 3, 2007·Nature Clinical Practice. Gastroenterology & Hepatology·Charles J Kahi, Douglas K Rex
Apr 1, 2009·Nature Reviews. Clinical Oncology·Perry J Pickhardt
Aug 6, 2009·Nature Reviews. Gastroenterology & Hepatology·Douglas K Rex
Dec 17, 2009·Clinics in Colon and Rectal Surgery·W Donald Buie, Anthony R MacLean
Nov 3, 2010·Clinics in Colon and Rectal Surgery·Timothy M Geiger, Rocco Ricciardi
Dec 15, 2006·The New England Journal of Medicine·Robert L BarclayRoger L Greenlaw
Sep 27, 2007·Journal of the National Cancer Institute·James E AllisonJoseph V Selby
Jul 29, 2010·Journal of the National Cancer Institute·Amy B KnudsenAnn G Zauber
Jan 10, 2012·Diseases of the Colon and Rectum·David A WestwoodSaxon J Connor
Nov 3, 2010·Current Opinion in Gastroenterology·Silvio W de Melo, Michael B Wallace
Nov 26, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·G TriboniasG A Paspatis
Oct 23, 2008·AJR. American Journal of Roentgenology·Perry J PickhardtSergio Morini
Apr 22, 2009·AJR. American Journal of Roentgenology·Perry J PickhardtDavid H Kim
Feb 25, 2010·World Journal of Gastroenterology : WJG·Otto Schiueh-Tzang Lin
Jul 19, 2012·World Journal of Gastroenterology : WJG·Peter D SiersemaDaniel C DeMarco
Jan 8, 2013·World Journal of Gastrointestinal Endoscopy·Naohisa YoshidaYuji Naito
Nov 13, 2004·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Perry J Pickhardt
Mar 2, 2013·Radiology·B Dustin PoolerPerry J Pickhardt
Apr 4, 2014·The New England Journal of Medicine·Douglas A CorleyCharles P Quesenberry
Feb 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Perry J PickhardtJamey P Weichert
Mar 13, 2014·Current Treatment Options in Gastroenterology·Nicholas Tutticci, Michael J Bourke

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