PMID: 2487142Sep 1, 1989Paper

Location of breakpoints within the major breakpoint cluster region (bcr) in 33 patients with bcr rearrangement-positive chronic myeloid leukemia (CML) with complex or absent Philadelphia chromosomes

Genes, Chromosomes & Cancer
I D DubéP H Pinkerton

Abstract

We report the sublocalization of the breakpoint in chromosome 22 in 33 patients with chronic myeloid leukemia (CML) who also had unusual marrow cytogenetics. In 23 patients, the leukemic clones were characterized by Philadelphia (Ph1) chromosomes that arose through complex translocations that involved three or more chromosomes. In the remaining ten patients, there were no detectable Ph1 chromosomes despite molecular evidence for the presence of rearrangements in the major breakpoint cluster region (bcr) of chromosome 22 in all cases. There was no significant difference between the two groups with respect to location of the breakpoints within the bcr. When these two groups of patients were combined, there was a significant excess of breakpoints in one segment of the bcr when compared to the distribution of breakpoints seen in 119 patients with simple 9;22 translocations. The difference in breakpoint distributions did not appear to be entirely attributable to differences between groups in disease duration at the time of study. These data support the notion that the unusual genetic recombinations that give rise to BCR/ABL fusion genes in CML involve specific DNA sequences of BCR (and possibly ABL) and additional, recombinogenic se...Continue Reading

References

Oct 15, 1988·Cancer Genetics and Cytogenetics·C M MorrisP H Fitzgerald
Oct 15, 1988·Cancer Genetics and Cytogenetics·M E WeinsteinS E Waintraub
Jan 1, 1987·Leukemia Research·R S Verma, M J Macera
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Citations

May 1, 1990·Genes, Chromosomes & Cancer·M Nibert, S Heim
Jan 1, 1991·Genes, Chromosomes & Cancer·A VerhestB Nedoszytko
Jun 1, 1995·Genes, Chromosomes & Cancer·A N MohamedF H Sarkar
May 1, 1993·Cancer Genetics and Cytogenetics·M SessaregoP F Pignatti
Nov 1, 1996·Cancer Genetics and Cytogenetics·G J González, M Notohamiprodjo
Jun 1, 1995·Cancer Genetics and Cytogenetics·D AbeliovichD Ben-Yehuda
Feb 22, 2005·Cancer Genetics and Cytogenetics·Juan Pablo Meza EspinozaJuan Ramón González García
Feb 1, 1997·Cancer Genetics and Cytogenetics·E S MartinS E Martin
Jul 1, 1997·Cancer Genetics and Cytogenetics·D PerkinsI Dubé
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T W McKeithanM M LeBeau
Jan 1, 1993·Leukemia & Lymphoma·F Mitelman
Jun 1, 1997·Baillière's Clinical Haematology·S O'BrienM J Siciliano
Apr 18, 2006·Cancer Genetics and Cytogenetics·Eric JeandidierUNKNOWN Groupe Français de Cytogénétique Hématologique (GFCH)
Dec 5, 2009·Best Practice & Research. Clinical Haematology·Jane Apperley

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