PMID: 9545490May 8, 1998Paper

Location of mouse and human genes corresponding to conserved canine olfactory receptor gene subfamilies

Mammalian Genome : Official Journal of the International Mammalian Genome Society
E A CarverL Stubbs

Abstract

Olfactory receptors are G protein-coupled, seven-transmembrane-domain proteins that are responsible for binding odorants in the nasal epithelium. They are encoded by a large gene family, members of which are organized in several clusters scattered throughout the genomes of mammalian species. Here we describe the mapping of mouse sequences corresponding to four conserved olfactory receptor genes, each representing separate, recently identified canine gene subfamilies. Three of the four canine genes detected related gene clusters in regions of mouse Chromosomes (Chrs) 2, 9, and 10, near previously mapped mouse olfactory genes, while one detected a formerly unidentified gene cluster located on mouse Chr 6. In addition, we have localized two human gene clusters with homology to the canine gene, CfOLF4, within the established physical map of Chr 19p. Combined with recently published studies, these data link the four conserved olfactory gene subfamilies to homologous regions of the human, dog, and mouse genomes.

References

May 1, 1990·Human Genetics·V C NguyenF Moreau-Gachelin
Jul 11, 1989·Nucleic Acids Research·R W WilsonA L Beaudet
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M S FeatherstoneD Duboule
Jul 11, 1986·Nucleic Acids Research·F QuanR A Gravel
Dec 1, 1995·Nature Genetics·L K AshworthA V Carrano
Sep 1, 1993·Genomics·M W SmithY Lin
Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·K F Manly
Jul 1, 1993·Nucleic Acids Research·A Bairoch, B Boeckmann
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·S L SullivanL B Buck
May 1, 1996·Genomics·R W DeBry, M F Seldin
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·L Issel-Tarver, J Rine
Sep 1, 1996·Genome Research·L D HillierM Marra
Jan 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·L StubbsL Lopez-Molina
Jan 1, 1997·Genetics·L Issel-Tarver, J Rine

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Citations

Apr 15, 1999·Annual Review of Neuroscience·P Mombaerts
Oct 3, 2006·Genome Biology·Ronny AloniDoron Lancet
Jan 22, 2002·Nature Neuroscience·Xinmin Zhang, Stuart Firestein
Jun 23, 1999·Current Opinion in Genetics & Development·P Mombaerts
May 5, 2001·Genome Research·G GlusmanD Lancet

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