Location-specific risk factors for intracerebral hemorrhage: Systematic review and meta-analysis.

Neurology
Wilmar M T JolinkCatharina J M Klijn

Abstract

To conduct a systematic review and meta-analysis of studies reporting on risk factors according to location of the intracerebral hemorrhage. We searched PubMed and Embase for cohort and case-control studies reporting ≥100 patients with spontaneous intracerebral hemorrhage that specified the location of the hematoma and reported associations with risk factors published until June 27, 2019. Two authors independently extracted data on risk factors. Estimates were pooled with the generic variance-based random-effects method. After screening 10,013 articles, we included 42 studies totaling 26,174 patients with intracerebral hemorrhage (9,141 lobar and 17,033 nonlobar). Risk factors for nonlobar intracerebral hemorrhage were hypertension (risk ratio [RR] 4.25, 95% confidence interval [CI] 3.05-5.91, I 2 = 92%), diabetes mellitus (RR 1.35, 95% CI 1.11-1.64, I 2 = 37%), male sex (RR 1.63, 95% CI 1.25-2.14, I 2 = 61%), alcohol overuse (RR 1.48, 95% CI 1.21-1.81, I 2 = 19%), underweight (RR 2.12, 95% CI 1.12-4.01, I 2 = 31%), and being a Black (RR 2.83, 95% CI 1.02-7.84, I 2 = 96%) or Hispanic (RR 2.95, 95% CI 1.69-5.14, I 2 = 71%) participant compared with being a White participant. Hypertension, but not any of the other risk factors, w...Continue Reading

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Citations

Jun 1, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Lieke JäkelMarcel M Verbeek
Aug 15, 2021·The Lancet. Planetary Health·Jamie I VerhoevenFrank-Erik de Leeuw
Aug 31, 2021·Journal of Alzheimer's Disease : JAD·Zhizhong ZhangXinfeng Liu
Oct 3, 2021·Current Cardiology Reports·Hae Young Baang, Kevin N Sheth
Oct 6, 2021·The Journal of Clinical Hypertension·Jun ShenFeng Xu
Oct 8, 2021·Continuum : Lifelong Learning in Neurology·Christa O'Hana S Nobleza

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