Locational and Directional Dependencies of Smooth Muscle Properties in Pig Urinary Bladder

Frontiers in Physiology
Mischa BorsdorfTobias Siebert

Abstract

The urinary bladder is a distensible hollow muscular organ, which allows huge changes in size during absorption, storage and micturition. Pathological alterations of biomechanical properties can lead to bladder dysfunction and loss in quality of life. To understand and treat bladder diseases, the mechanisms of the healthy urinary bladder need to be determined. Thus, a series of studies focused on the detrusor muscle, a layer of urinary bladder made of smooth muscle fibers arranged in longitudinal and circumferential orientation. However, little is known about whether its active muscle properties differ depending on location and direction. This study aimed to investigate the porcine bladder for heterogeneous (six different locations) and anisotropic (longitudinal vs. circumferential) contractile properties including the force-length-(FLR) and force-velocity-relationship (FVR). Therefore, smooth muscle tissue strips with longitudinal and circumferential direction have been prepared from different bladder locations (apex dorsal, apex ventral, body dorsal, body ventral, trigone dorsal, trigone ventral). FLR and FVR have been determined by a series of isometric and isotonic contractions. Additionally, histological analyses were cond...Continue Reading

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Citations

Apr 9, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Mohammad Ayodhia SoebadiDirk De Ridder
Dec 29, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Robin TrostorfMarkus Böl
Apr 27, 2021·Pflügers Archiv : European journal of physiology·Mischa BorsdorfTobias Siebert
May 26, 2021·Acta Biomaterialia·Alyssa HuntingtonRaffaella De Vita

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