Locations and morphologies of sympathetically correlated neurons in the T(10) spinal segment of the rat

Brain Research
Xiaorui TangLawrence P Schramm

Abstract

We precisely localized and morphologically characterized sympathetically correlated neurons in the acutely transected spinal cord of the rat. We have shown that these neurons are likely members of the spinal networks that generate sympathetic activity after spinal cord transection. In humans with injured spinal cords, these networks are responsible for hypertensive crises that occur in response to ordinarily innocuous stimuli. We recorded from neurons in the dorsal horn of the T(10) spinal segment of anesthetized rats after acute spinal cord transection at C(2). Neurons with activities closely correlated to renal sympathetic nerve activity (RSNA) were considered to be putative components of spinal sympathetic systems. These neurons had receptive fields on the left flank and abdomen. After characterizing their ongoing activities, receptive fields, and degrees of correlation with RSNA, we juxtacellularly labeled neurons with biotinamide and subsequently reconstructed their somas and dendrites histologically. Confirming our earlier studies, sympathetically correlated neurons were found in dorsal horn laminae III, IV, and V. For the first time, we also identified sympathetically correlated neurons in laminae I and II. The dendrites...Continue Reading

Citations

Mar 14, 2009·Experimental Brain Research·D M MillerB J Yates
May 5, 2009·Journal of Biomedical Science·Chun-Kuei SuChok-Yung Chai
Mar 17, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adrian A CameronAlexander G Rabchevsky
May 23, 2014·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Lucie RiedlbauchováJakub Schlenker
May 3, 2007·Expert Opinion on Pharmacotherapy·Jay KhastgirPaul Abrams
Jun 16, 2009·Journal of Chemical Neuroanatomy·Ida J Llewellyn-Smith

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