Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees

Biological Psychiatry
Thomas G SchulzeFrancis J McMahon

Abstract

We have reported genetic linkage between bipolar disorder and markers on chromosome 6q16.3-22.1 in the National Institute of Mental Health Genetics Initiative wave 3 pedigrees. Here we test for: 1) robustness of the linkage to differing analysis methods, genotyping error, and gender-specific maps; 2) parent-of-origin effects; and 3) interaction with markers within the schizophrenia linkage region on chromosome 6p. Members of 245 families ascertained through a sibling pair affected with bipolar I or schizoaffective-bipolar disorder were genotyped with 18 markers spanning chromosome 6. Nonparametric linkage analysis was performed. Linkage to 6q is robust to analysis method, gender-specific map differences, and genotyping error. The locus confers a 1.4-fold increased risk. Affected siblings share the maternal more often than the paternal chromosome (p =.006), which could reflect a maternal parent-of-origin effect. There is a positive correlation between family-specific linkage scores on 6q and those on 6p22.2 (r =.26; p <.0001). Linkage analysis for each locus conditioned on evidence of linkage to the other increases the evidence for linkage at both loci (p <.0005). Logarithm of the odds (LOD) scores increased from 2.26 to 5.42 on...Continue Reading

References

Oct 1, 1992·Archives of General Psychiatry·J P RiceC Miller
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J Ott
Jan 1, 1972·Archives of General Psychiatry·J P FeighnerR Munoz
Aug 1, 1982·Archives of General Psychiatry·J F LeckmanM M Weissman
Oct 1, 1982·Archives of General Psychiatry·E S GershonW E Bunney
Feb 1, 1995·Nature Genetics·I K TempleJ P Shield
Apr 9, 1996·American Journal of Medical Genetics·E S GershonW H Berrettini
May 31, 1997·American Journal of Medical Genetics·S D Detera-WadleighE S Gershon
Nov 5, 1997·American Journal of Human Genetics·A Kong, N J Cox
Dec 11, 1997·Nature·A P MonaghanG Schütz
Dec 18, 1997·American Journal of Human Genetics·F J McMahonJ R DePaulo
Apr 10, 1999·Human Molecular Genetics·A PhilippeL van Malldergerme
Dec 11, 1999·Nucleic Acids Research·D R MaglottK D Pruitt
Mar 31, 2000·American Journal of Human Genetics·J A DouglasK Lange
Dec 29, 2000·Molecular Psychiatry·H K ManjiG Chen
Jun 19, 2001·Annals of Medicine·S D Detera-Wadleigh
Dec 26, 2001·Archives of General Psychiatry·F J McMahonJ R DePaulo
Mar 29, 2002·Molecular Psychiatry·S JamainUNKNOWN Paris Autism Research International Sibpair (PARIS) Study
May 17, 2002·Nature·Robin S B WilliamsAdrian J Harwood
Jun 18, 2002·Journal of Neurochemistry·Wen-Hui HuJohn R Bethea
Dec 10, 2002·Journal of Medical Genetics·I K Temple, J P H Shield
Feb 1, 2003·Biological Psychiatry·Thomas G SchulzeFrancis J McMahon
Jun 28, 2003·American Journal of Human Genetics·Veronica J Vieland, Jian Huang
Nov 18, 2003·American Journal of Human Genetics·Ann Van Den BogaertSven Cichon

❮ Previous
Next ❯

Citations

Jul 9, 2008·Archives of General Psychiatry·Peter P ZandiUNKNOWN National Institute of Mental Health Genetics Initiative Bipolar Disorder Consortium
Feb 28, 2008·Molecular Psychiatry·H Le-NiculescuA B Niculescu
Dec 31, 2010·Psychiatric Genetics·Sarah M HartzUNKNOWN NIMH Genetics Initiative Bipolar Disorder Consortium
Jan 24, 2007·Psychiatry and Clinical Neurosciences·Tadafumi Kato
Sep 12, 2008·Biological Reviews of the Cambridge Philosophical Society·Bernard Crespi
May 2, 2009·Disease Models & Mechanisms·Oz MalkesmanHusseini K Manji
Jul 6, 2014·Human Molecular Genetics·Kevin A StraussErik G Puffenberger
Nov 8, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ajaykumar N SharmaJoao Quevedo
Oct 19, 2011·Pharmacology & Therapeutics·James Offord
May 11, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Mirko ManchiaJames L Kennedy
Nov 26, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·H Le-NiculescuA B Niculescu
Oct 24, 2007·Journal of Traumatic Stress·Karestan C Koenen
Feb 6, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·H Le-NiculescuA B Niculescu
Sep 22, 2011·Clinical Genetics·A Guilmatre, A J Sharp
Sep 28, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jo KnightJohn P Rice
Jun 17, 2014·Biochimica Et Biophysica Acta·Mohammed M Islam, Chun-Li Zhang
Oct 21, 2015·Frontiers in Molecular Neuroscience·Veronica MereloAlfredo Bellon
Jun 16, 2012·RNA Biology·Chiara Pastori, Claes Wahlestedt
Mar 21, 2012·Psychiatry Research·Woojae MyungDoh Kwan Kim
Apr 29, 2014·Journal of Affective Disorders·Zuowei WangYiru Fang
Mar 26, 2016·Expert Review of Neurotherapeutics·Liang PengAlexei Verkhratsky
Apr 11, 2006·Harvard Review of Psychiatry·James B Potash
Feb 13, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jason L ChoiIvana Delalle
Sep 7, 2016·Translational Psychiatry·M-R RautiainenJ Tiihonen
Oct 11, 2007·Nature Reviews. Neuroscience·Lawrence S WilkinsonAnthony R Isles
Feb 3, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·H Le-NiculescuA B Niculescu
Apr 18, 2008·Human Heredity·Lars AngquistLeif Groop
Oct 22, 2008·International Archives of Occupational and Environmental Health·Jesper KristiansenKaren Søgaard
Jun 29, 2005·Molecular Psychiatry·A Lyons-WarrenA Sawa
Jan 5, 2018·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Alberto Bocchetta, Francesco Traccis
Mar 3, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jack F SamuelsGerald Nestadt
Feb 18, 2019·Journal of Affective Disorders·Arezou SayadSoudeh Ghafouri-Fard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.