Loci on murine chromosomes 7 and 13 that modify the phenotype of the NOA mouse, an animal model of atopic dermatitis

Journal of Human Genetics
O WatanabeY Nakamura

Abstract

The NOA (Naruto Research Institute Otsuka Atrichia) mouse is an animal model of allergic or atopic dermatitis, a condition characterized by ulcerative skin lesions with accumulation of mast cells and increased serum IgE. We reported earlier that a major gene responsible for dermatitis in the NOA mouse lay in the middle of chromosome 14, and that the incidence of disease clearly differed according to parental strain; the mode of inheritance was autosomal recessive with incomplete penetrance. In the study reported here, we searched for genes that might modify the NOA phenotype, and we identified two candidate loci that appeared to contain genes capable of modifying atopic or allergic dermatitis, one in the middle of chromosome 7 (chi2 = 14.66; P = 0.00013 for D7Mit62) and the other in the telomeric region of chromosome 13 (chi2 = 15.352; P = 0.000089 for D13Mit147). These loci correspond to regions of synteny in human chromosomes where linkages to asthma, atopy, or related phenotypes, such as serum IgE levels, have been documented.

Citations

Apr 3, 2002·The Journal of Experimental Medicine·Michael GirardiRobert E Tigelaar
Nov 16, 2004·International Archives of Allergy and Immunology·Jan GutermuthThilo Jakob
Feb 13, 2003·Current Opinion in Allergy and Clinical Immunology·William O C M Cookson, Miriam F Moffatt
Jan 24, 2014·Molecular Medicine Reports·Zhong-Kui ZhangSi-Xian He
Jul 28, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshibumi MatsushimaHiromichi Yonekawa

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