PMID: 6106046Jan 1, 1980Paper

Locomotor activity and catecholamine receptor binding in adult normotensive and spontaneously hypertensive rats

Journal of Neural Transmission
K Hellstrand, J Engel

Abstract

The binding of 3H-WB 4101, an alpha 1-adrenoceptor antagonist, to membranes of the cerebral cortex, the hypothalamus, and the lower brainstem was examined in adult spontaneously hypertensive (SH) rats and in normotensive Wistar Kyoto (WK) controls. The specific binding of 3H-WB 4101 (0.33 nM) was significantly higher in homogenates from the cerebral cortex of SH rats as compared to WK rats. No differences were detected between SH and WK rats in the specific binding of 3H-spiroperidol (2.25 nM), a dopamine receptor antagonist, to membranes from the corpus striatum and the limbic forebrain. The locomotor activity was significantly higher in SH rats as compared to WK controls, in all probability due to a lack of habituation to environmental change. It is suggested that the high reactivity of SH rats in related to a dysfunction in the noradrenergic neurons in the central nervous system.

Citations

Jan 1, 1988·Clinical and Experimental Hypertension. Part A, Theory and Practice·M van den Buuse, W de Jong
Sep 1, 1984·Journal of Autonomic Pharmacology·L G Howes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.