Locomotor activity and dopamine synthesis following 1 and 15 days of withdrawal from repeated apomorphine treatments

Pharmacology, Biochemistry, and Behavior
J K RowlettM T Bardo

Abstract

In two experiments, the effects of repeated apomorphine treatments on locomotor activity and terminal field dopamine synthesis was assessed after either a 1- or 15-day withdrawal period. In the first experiment, rats (n = 11/group) were treated with apomorphine (1.0 mg/kg, s.e.) or vehicle and tested for locomotor activity daily for 10 days. Fifteen days after the last repeated treatment, all rats received 1.0 mg/kg apomorphine and were tested for locomotor activity. Locomotor sensitization developed over the 10 day period and was still evident after the 15-day withdrawal period. In the second experiment rats (n = 11/group) were treated with apomorphine (1.0 mg/kg, s.c.) or vehicle and tested for locomotor activity daily for 10 days. Dopamine synthesis was assessed following 1 or 15 days of withdrawal by measuring dihydroxyphenylalanine (DOPA) accumulation (after DOPA decarboxylase inhibition with NSD-1015) in striatum and nucleus accumbens-olfactory tuberele. As in the first experiment, rats treated with repeated apomorphine showed locomotor sensitization over the 10 days, relative to controls. Dopamine synthesis was reliably enhanced in the striatum, but not nucleus accumbens-olfactory tuberele, following both 1- and 15-day w...Continue Reading

References

Oct 1, 1989·Pharmacology, Biochemistry, and Behavior·B A Mattingly, J K Rowlett
Jan 1, 1989·Pharmacology, Biochemistry, and Behavior·J Peris, N R Zahniser
Sep 1, 1981·Pharmacology, Biochemistry, and Behavior·R Kuczenski, N J Leith
Mar 14, 1995·European Journal of Pharmacology·M Jeziorski, F J White
Mar 1, 1996·Pharmacology, Biochemistry, and Behavior·B A MattinglyK Rase

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Citations

Apr 28, 2001·Pharmacology, Biochemistry, and Behavior·B A MattinglyM Abel
Aug 5, 2008·Pharmacology, Biochemistry, and Behavior·Priscila Quintanilha BragaMarinete Pinheiro Carrera
Dec 22, 2014·Pharmacology, Biochemistry, and Behavior·Breno Garone SantosMarinete Pinheiro Carrera

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