Locomotor activity and resting local field potential oscillatory rhythms of 6-OHDA mouse model of Parkinson's disease in response to acute and repeated treatments with L-dopa.

Neuroscience Letters
Kirati NiyomratEkkasit Kumarnsit

Abstract

Phase-amplitude coupling (PAC) of local field potential (LFP) has been recognized as higher-order representation of brain states. Neuronal loss in the striatum leads to Parkinson's disease (PD) symptoms and modifies LFP oscillation. However, PAC in the striatum of PD mouse model induced by 6-hydroxydopamne (6-OHDA) remained to be investigated. Male Swiss albino ICR mice were implanted with intracranial electrode and injected with 6-OHDA to the left striatum. Levodopa (L-dopa) (10 mg/kg, oral) was used for treatment once a day from day 15-19. Locomotor activity and resting LFP signals were selectively analyzed on day 15 and 19. One-way ANOVA revealed significant decreases in travelled distance induced by 6-OHDA on both days (p ≤ 0.05). However, the decreased travelled distances were significantly reversed by L-dopa. On day 15, LFP powers of theta, alpha, beta and low gamma waves were significantly increased by 6-OHDA injection and the powers of beta and low gamma were significantly reversed to control level by treatment with L-dopa. On day 19, LFP powers of delta, theta, alpha, beta and low gamma waves were significantly increased by 6-OHDA injection and the powers of low gamma were significantly reversed to control level by tre...Continue Reading

References

Jan 1, 1990·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·T BrannanM Yahr
Nov 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·Adriano B L TortHoward Eichenbaum
Mar 23, 2010·Brain : a Journal of Neurology·Marjan JahanshahiAndrew J Lees
Apr 18, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Ronald B PostumaTjalf Ziemssen
Dec 21, 2012·General Physiology and Biophysics·Katarina JaskovaDana Jurkovicova
Jun 3, 2014·Molecular Neurodegeneration·Xi LuKaren L O'Malley
Apr 12, 2016·Frontiers in Systems Neuroscience·Jovana J BelićJeanette Hellgren Kotaleski
Sep 25, 2017·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Christos TsiokosNader Pouratian
Mar 14, 2019·Free Radical Biology & Medicine·Laura B ValdezAna Navarro
Jul 1, 2015·The Journal of Physiological Sciences : JPS·Chayaporn ReakkamnuanEkkasit Kumarnsit
Sep 10, 2020·Neuroscience·Arun Singh, Stella M Papa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.