Locomotor function after long-duration space flight: effects and motor learning during recovery.

Experimental Brain Research
Ajitkumar P MulavaraJacob J Bloomberg

Abstract

Astronauts returning from space flight and performing Earth-bound activities must rapidly transition from the microgravity-adapted sensorimotor state to that of Earth's gravity. The goal of the current study was to assess locomotor dysfunction and recovery of function after long-duration space flight using a test of functional mobility. Eighteen International Space Station crewmembers experiencing an average flight duration of 185 days performed the functional mobility test (FMT) pre-flight and post-flight. To perform the FMT, subjects walked at a self selected pace through an obstacle course consisting of several pylons and obstacles set up on a base of 10-cm-thick, medium-density foam for a total of six trials per test session. The primary outcome measure was the time to complete the course (TCC, in seconds). To assess the long-term recovery trend of locomotor function after return from space flight, a multilevel exponential recovery model was fitted to the log-transformed TCC data. All crewmembers exhibited altered locomotor function after space flight, with a median 48% increase in the TCC. From the fitted model we calculated that a typical subject would recover to 95% of his/her pre-flight level at approximately 15 days po...Continue Reading

References

May 22, 1992·Annals of the New York Academy of Sciences·L R YoungS Modestino
May 22, 1992·Annals of the New York Academy of Sciences·W H PaloskiD L Harm
Sep 16, 1993·Nature·A Karni, D Sagi
Apr 1, 1996·Journal of Experimental Psychology. Human Perception and Performance·G M Redding, B Wallace
Jan 1, 1997·Experimental Brain Research·C S LayneJ J Bloomberg
Apr 1, 1997·Mayo Clinic Proceedings·B A HarrisE C Rosenow
Aug 1, 1997·Current Opinion in Neurobiology·A Karni, G Bertini
Jan 10, 1998·Experimental Brain Research·D J NewmanJ J Bloomberg
Oct 31, 1998·Brain Research. Brain Research Reviews·M F ReschkeV McDonald
Nov 25, 1998·Experimental Brain Research·R RollV Gurfinkel
Jan 14, 1999·Journal of Applied Physiology·G AntonuttoP E di Prampero
Aug 5, 2000·Journal of Applied Physiology·R H FittsJ J Widrick
Nov 9, 2000·Journal of Neurophysiology·D M Clower, D Boussaoud
Feb 22, 2001·Journal of Applied Physiology·C S LayneJ J Bloomberg
Sep 1, 1981·Acta Astronautica·I B KozlovskayaO P Koserenko
Oct 16, 2001·Journal of Neurophysiology·R BoyleS M Highstein
Jun 12, 2002·Journal of Motor Behavior·Gordon M Redding, Benjamin Wallace
May 8, 2003·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·Jacob J Bloomberg, Ajitkumar P Mulavara
Mar 10, 2004·Journal of Cognitive Neuroscience·Rachael D Seidler
Nov 27, 2004·Experimental Brain Research·Otmar Bock
May 13, 2005·Journal of Neurophysiology·Daniel S Marigold, Aftab E Patla
Dec 6, 2005·Experimental Brain Research·Otmar Bock, Michaela Girgenrath
Apr 7, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pietro Mazzoni, John W Krakauer
Oct 25, 2006·Experimental Brain Research·Jason T RichardsJacob J Bloomberg
May 15, 2007·Nature Neuroscience·Konrad P KordingReza Shadmehr
Jan 9, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jacques LuautéPatrik Vuilleumier
Sep 2, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jongsik ChunRita R Colwell
Oct 7, 2009·Journal of Cognitive Neuroscience·Joaquin A AngueraRachael D Seidler

❮ Previous
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Citations

Jun 10, 2006·Experimental Brain Research·Steven T MooreHelen S Cohen
Feb 26, 2011·Experimental Brain Research·Crystal D BatsonJacob J Bloomberg
Mar 29, 2011·Experimental Brain Research·Ajitkumar P MulavaraJacob J Bloomberg
Nov 19, 2010·Cerebral Cortex·Sara Ann SimpsonJason J S Barton
Jun 6, 2012·PloS One·Ranieri CanceddaSalvatore Pignataro
Sep 22, 2015·Frontiers in Systems Neuroscience·Vincent KoppelmansRachael D Seidler
Oct 7, 2015·Frontiers in Systems Neuroscience·Jacob J BloombergAjitkumar P Mulavara
Jul 15, 2015·Experimental Brain Research·Mukul MukherjeeNicholas Stergiou
Jul 18, 2016·NeuroImage·Kaitlin CassadyRachael Seidler
Sep 8, 2016·Frontiers in Systems Neuroscience·Peng YuanRachael D Seidler
Mar 13, 2018·Human Brain Mapping·Peng YuanRachael Seidler
Nov 23, 2017·Frontiers in Physiology·Francesco LacquanitiMyrka Zago
Mar 1, 2018·Journal of Neurophysiology·Peng YuanRachael D Seidler
Mar 23, 2018·Journal of Applied Physiology·Marie MortreuxSeward B Rutkove
Apr 6, 2018·Medicine and Science in Sports and Exercise·Ajitkumar P MulavaraJacob J Bloomberg
Sep 25, 2017·Journal of Motor Behavior·M F L RuitenbergR D Seidler
Oct 12, 2018·PloS One·Vincent KoppelmansRachael D Seidler
Oct 18, 2018·Journal of Neurophysiology·Raquel C Galvan-GarzaLaurence R Young
May 29, 2018·Journal of Applied Biomechanics·Stephen M GlassF J Haran
Feb 13, 2016·Journal of Applied Physiology·Donald E Watenpaugh
Nov 21, 2019·Journal of Neurophysiology·Jordan B Dixon, Torin K Clark
Apr 27, 2017·Frontiers in Systems Neuroscience·Rahul GoelAjitkumar P Mulavara
Sep 13, 2020·Science Advances·Steven JillingsBen Jeurissen
Sep 27, 2018·Scientific Reports·M F L RuitenbergR D Seidler
Jul 25, 2019·Frontiers in Physiology·Ekaterina PechenkovaInessa Kozlovskaya
Jan 31, 2020·Frontiers in Systems Neuroscience·Kathleen E HupfeldRachael D Seidler
Jun 29, 2017·European Biophysics Journal : EBJ·Florian P M Kohn, Ramona Ritzmann
Jun 27, 2017·NPJ Microgravity·Vincent KoppelmansRachael D Seidler
Sep 14, 2018·NPJ Microgravity·Kyoung Jae KimMichael C Schubert
Aug 31, 2020·Cerebral Cortex Communications·Kathleen E HupfeldUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
May 5, 2020·Frontiers in Physiology·Ashleigh MarchantJacob J Bloomberg
Nov 28, 2018·OTO Open : the Official Open Access Journal of the American Academy of Otolaryngology--Head and Neck Surgery Foundation·Millard F ReschkeGilles R Clément
Dec 10, 2020·Journal of Neurophysiology·Lauren A BankerRachael D Seidler
Jan 18, 2021·Neuroscience and Biobehavioral Reviews·K E HupfeldR D Seidler
May 15, 2021·Frontiers in Systems Neuroscience·Timothy R MacaulayJacob J Bloomberg

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