PMID: 6411289Jul 1, 1983Paper

Locomotor hyperactivity in neonatal rats following electrolytic lesions of mesocortical dopamine neurons

Brain Research
T G HeffnerL S Seiden

Abstract

These experiments examined the effects on locomotor activity of brain lesions that destroyed either mesocortical or nigrostriatal dopamine (DA) neuronal projections in neonatal rats. Electrolytic lesions of the medial ventral tegmental area in 4-day-old rats reduced the content of DA within the frontal cortex and septum by 42-57% and resulted in a 2-fold increase in locomotor activity during days 22-24 of life. In contrast, bilateral electrolytic lesions of the substantia nigra in 4-day-old rats reduced the content of DA within the caudate putamen by 68%, but failed to alter locomotor activity during days 22-24 of life. These results suggest that loss of mesocortical DA neurons may underlie the locomotor hyperactivity seen following brain DA-depleting 6-hydroxydopamine injections in neonatal rats and that these mesocortical DA neurons may normally influence the ontogeny of locomotion in the rat.

References

Feb 15, 1978·The Journal of Comparative Neurology·R Y Moore
Mar 18, 1977·Brain Research·D GaleyM Le Moal
Mar 1, 1979·Journal of Neuroscience Methods·A HellerC Fernandez
Sep 1, 1979·The Journal of Comparative Neurology·O T Phillipson
Jan 1, 1978·Annual Review of Neuroscience·R Y Moore, F E Bloom
Nov 1, 1974·Journal of Comparative and Physiological Psychology·J F MarshallP Teitelbaum
May 1, 1972·European Journal of Pharmacology·B R JacksJ P Cordeau
Sep 1, 1980·Pharmacology, Biochemistry, and Behavior·T G HeffnerL S Seiden

❮ Previous
Next ❯

Citations

Jan 1, 1984·Progress in Neurobiology·J J Feigenbaum, J Yanai
Jan 1, 1994·Brain Research Bulletin·R M KostrzewaR W Fuller
Feb 20, 2016·Pharmacology, Biochemistry, and Behavior·Fumio SoedaKazuo Takahama
Nov 1, 1989·Behavioural Brain Research·F B Weihmuller, J P Bruno
Aug 16, 2005·Brain Research. Developmental Brain Research·P J Boyce, J M Finlay
Nov 1, 1996·The British Journal of Psychiatry : the Journal of Mental Science·K W BrownD Foley
Sep 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·D Healy
Jan 1, 1988·The British Journal of Psychiatry : the Journal of Mental Science·R W Kerwin
Sep 27, 2018·The European Journal of Neuroscience·Carole MorelMing-Hu Han
Dec 17, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Arun Kumar MahatoMart Saarma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.