Locoregional therapies for hepatocellular carcinoma: a critical review from the surgeon's perspective

Annals of Surgery
Ronnie Tung-Ping PoonJohn Wong

Abstract

This article reviews the current results of various locoregional therapies for hepatocellular carcinoma (HCC), with special reference to the implications for surgeons. Resection or transplantation is the treatment of choice for HCC, but most patients are not suitable candidates. The past decade has witnessed the development of a variety of locoregional therapies for HCC. Surgeons are faced with the challenge of adopting these therapies in the management of patients with resectable or unresectable HCC. A review of relevant English-language articles was undertaken based on a Medline search from January 1990 to August 2001. Retrospective studies suggested that transarterial chemoembolization is an effective treatment for inoperable HCC, but its perceived benefit for survival has not been substantiated in randomized trials, presumably because its antitumor effect is offset by its adverse effect on liver function. Nonetheless, it remains a widely used palliative treatment for HCC not amenable to resection or ablative therapies, and it also plays an important role as a treatment of postresection recurrence and as a pretransplant therapy for transplantable HCC. Better patient selection, selective segmental chemoembolization, and treat...Continue Reading

References

Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R VilanaJ Rodés
Sep 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F YoshimiM Imawari
Jan 1, 1992·Cancer Chemotherapy and Pharmacology·C F Yang, Y J Ho
Apr 1, 1992·American Journal of Surgery·H BismuthA Roche
Mar 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D VetterR Bockel
Nov 1, 1990·Journal of Gastroenterology and Hepatology·M EbaraY Kondo
Apr 1, 1989·The Surgical Clinics of North America·T S Ravikumar, G D Steele
Mar 1, 1988·Cancer Treatment Reviews·S R NerenstoneM A Friedman
May 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L MondazziG Idèo
Sep 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J BruixL Boix
May 1, 1993·AJR. American Journal of Roentgenology·S ShiinaA Terano
May 11, 1995·The New England Journal of Medicine·UNKNOWN Groupe d'Etude et de Traitement du Carcinome Hépatocellulaire
Nov 1, 1994·The British Journal of Surgery·S BhattacharyaK E Hobbs
Aug 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R IzumiI Miyazaki

❮ Previous
Next ❯

Citations

Jun 16, 2012·World Journal of Surgery·Tan To CheungSheung Tat Fan
Oct 27, 2004·European Radiology·Ahmed MoumouhJean-Pierre Tasu
Dec 17, 2008·Journal of Hepato-biliary-pancreatic Surgery·Tsuyoshi IchikawaShoji Kubo
Apr 17, 2009·Journal of Hepato-biliary-pancreatic Surgery·Tan To CheungSheung Tat Fan
Aug 19, 2007·Lasers in Medical Science·Tarek F ElwakilMahmoud S Elbasiouny
Nov 14, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Alfredo GuglielmiCalogero Iacono
Apr 29, 2010·Current Oncology Reports·Bernardino RamponeGiuseppe Confuorto
Nov 6, 2004·Current Treatment Options in Gastroenterology·Josep M Llovet
Jan 22, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·H D González, J Figueras
Oct 12, 2012·Annals of Nuclear Medicine·Wengen ChenAbass Alavi
Mar 26, 2013·Biomaterials·Scott H MedinaMohamed E H Elsayed
Jan 23, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S J WigmoreO J Garden
May 26, 2005·International Journal of Radiation Oncology, Biology, Physics·Zhao-Chong ZengJian-Hua Wang
Mar 22, 2005·Surgical Oncology·Kelvin K Ng, Ronnie T Poon
Nov 29, 2002·Seminars in Roentgenology·Douglas E Ramsey, Jean-Francois H Geschwind
Mar 18, 2011·Japanese Journal of Clinical Oncology·Tadatoshi Takayama
Oct 24, 2002·Journal of Clinical Gastroenterology·Massimo Di MaioBruno Daniele
Nov 25, 2003·Annals of Surgery·Jacques BelghitiReza Kianmanesh
Jun 17, 2010·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Zhihua LiuHuanlong Qin
Aug 21, 2008·Journal of Gastroenterology and Hepatology·Hyunchul RhimWon Jae Lee
Sep 12, 2008·World Journal of Surgical Oncology·Omar BarakatR Patrick Wood
Mar 3, 2004·Annals of Surgical Oncology·Ronnie Tung-Ping PoonSheung-Tat Fan
Apr 14, 2005·Annals of Surgical Oncology·Aali J Sheen, Ajith K Siriwardena
Feb 1, 2008·Annals of Surgical Oncology·Roberta W C PangRonnie T P Poon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.