LocSigDB: a database of protein localization signals

Database : the Journal of Biological Databases and Curation
Simarjeet NegiChittibabu Guda

Abstract

LocSigDB (http://genome.unmc.edu/LocSigDB/) is a manually curated database of experimental protein localization signals for eight distinct subcellular locations; primarily in a eukaryotic cell with brief coverage of bacterial proteins. Proteins must be localized at their appropriate subcellular compartment to perform their desired function. Mislocalization of proteins to unintended locations is a causative factor for many human diseases; therefore, collection of known sorting signals will help support many important areas of biomedical research. By performing an extensive literature study, we compiled a collection of 533 experimentally determined localization signals, along with the proteins that harbor such signals. Each signal in the LocSigDB is annotated with its localization, source, PubMed references and is linked to the proteins in UniProt database along with the organism information that contain the same amino acid pattern as the given signal. From LocSigDB webserver, users can download the whole database or browse/search for data using an intuitive query interface. To date, LocSigDB is the most comprehensive compendium of protein localization signals for eight distinct subcellular locations. Database URL: http://genome....Continue Reading

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Citations

Sep 30, 2015·Methods : a Companion to Methods in Enzymology·Zhonghao Liu, Jianjun Hu
Jun 28, 2016·BMC Genomics·Mikael-Jonathan LuceMichelle S Scott
May 12, 2017·Nano Convergence·Teruyuki Nagamune
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May 29, 2021·Frontiers in Microbiology·Padhmanand SudhakarSéverine Vermeire
Oct 31, 2020·Molecular Pharmaceutics·Francisco E Lopez-SalasDaniel Martinez-Fong
Nov 3, 2017·Neuron·Benjamin R RostPeter Hegemann

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Software Mentioned

UniProt
KDEL
MySQL
Linux
NLSdb
Apache HTTP Server
LAMP (
LocSigDB
TrEMBL
Perl

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