PMID: 9187321May 9, 1997Paper

Locus coeruleus activation by colon distention: role of corticotropin-releasing factor and excitatory amino acids

Brain Research
S M LechnerR J Valentino

Abstract

The present study was designed to elucidate the neurotransmitters involved in activation of the noradrenergic nucleus, locus coeruleus, by distention of the distal colon. Locus coeruleus spontaneous discharge rate was recorded from halothane-anesthetized rats before, during and after distention of the colon produced by inflation of a balloon catheter with varying volumes of water. Locus coeruleus activation by colon distention was volume-dependent and reversible. Activation of cortical electroencephalographic activity was temporally correlated with locus coeruleus activation during colon distention and prolonged distention (greater than 2 min) resulted in tachyphalaxis to both locus coeruleus and cortical electroencephalographic activation. The corticotropin-releasing factor antagonist, DPheCRF(12-41), administered intracerebroventricularly (3 microg) or microinfused into the locus coeruleus (10 ng) significantly attenuated locus coeruleus activation produced by lower, but not higher magnitudes of colon distention, implicating corticotropin-releasing factor afferents to the locus coeruleus in this response. Consistent with this, prior exposure to 30 min of footshock stress, which desensitizes locus coeruleus neurons to corticot...Continue Reading

Citations

Jun 18, 2015·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Hong-Chul BaeEun-Cheol Park
Mar 3, 2005·Journal of Gastroenterology and Hepatology·Vikram Bhatia, Rakesh K Tandon
Mar 19, 2003·Alimentary Pharmacology & Therapeutics·H Mertz
Jun 15, 2001·The Journal of Comparative Neurology·R J ValentinoE J Van Bockstaele
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Tracy L Bale, Wylie W Vale
Jan 28, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Darcie A KiddooDimitri E Grigoriadis
Jul 16, 2008·Current Gastroenterology Reports·Ashis V Barad, Miguel Saps
Dec 8, 2010·Nature Reviews. Urology·Rita J ValentinoStephen A Zderic
Jan 9, 2019·Frontiers in Neuroscience·Elba Campos-LiraJerome D Swinny
Jun 5, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Garth BissetteGregory Ordway
Dec 23, 2003·The European Journal of Neuroscience·Marie-Laure Rouzade-DominguezRita J Valentino
Jun 15, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J TayamaS Fukudo
Feb 7, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P AnandL van Oudenhove
Jul 6, 2006·The European Journal of Neuroscience·Beverly A S ReyesElisabeth J Van Bockstaele
Feb 24, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Paul E Holtzheimer, Charles B Nemeroff
Apr 11, 2012·Cellular and Molecular Neurobiology·Debra A Bangasser, Rita J Valentino
Dec 5, 2017·ELife·Anitha ManoharRita J Valentino
Jun 14, 2001·Journal of Clinical Pharmacology·A TodorovaW Dimpfel
Jul 21, 2005·The European Journal of Neuroscience·Beverly A S ReyesElisabeth J Van Bockstaele
Jul 21, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C SmithA Miranda
Nov 15, 2008·The Journal of Comparative Neurology·B A S ReyesE J van Bockstaele
Apr 15, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Steven M BermanEmeran A Mayer
Jan 23, 2015·Journal of Neurogastroenterology and Motility·Yvette Taché, Mulugeta Million
Sep 12, 2000·Current Gastroenterology Reports·H R Mertz
May 27, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B Greenwood-Van MeerveldD A Myers
Mar 1, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Muriel LaraucheJames A McRoberts
Aug 24, 2011·Journal of Neurogastroenterology and Motility·Muriel LaraucheYvette Taché
Nov 21, 2012·Acta Physiologica·D J Griffiths, C J Fowler
Nov 18, 2006·Expert Opinion on Pharmacotherapy·Paul E Holtzheimer, Charles B Nemeroff
Apr 3, 2008·The Journal of Comparative Neurology·B A S ReyesE J Van Bockstaele
Jan 31, 2018·Scientific Reports·Chen YanovichAlbert Pinhasov
Nov 2, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J SuS Fukudo
Jul 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth RickenbacherRita J Valentino
Jan 16, 2003·Physiology & Behavior·Alan F SvedBruce S Rabin
Jul 5, 2001·Physiology & Behavior·E J Van BockstaeleR J Valentino
Apr 2, 2003·Brain Research. Brain Research Reviews·Craig W Berridge, Barry D Waterhouse

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.