Locus coeruleus is a central chemoreceptive site in toads

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Carolina R Noronha-de-SouzaLuciane H Gargaglioni

Abstract

The locus coeruleus (LC) has been suggested as a CO2 chemoreceptor site in mammals. This nucleus is a mesencephalic structure of the amphibian brain and is probably homologous to the LC in mammals. There are no data available for the role of LC in the central chemoreception of amphibians. Thus the present study was designed to investigate whether LC of toads (Bufo schneideri) is a CO2/H+ chemoreceptor site. Fos immunoreactivity was used to verify whether the nucleus is activated by hypercarbia (5% CO2 in air). In addition, we assessed the role of noradrenergic LC neurons on respiratory and cardiovascular responses to hypercarbia by using 6-hydroxydopamine lesion. To further explore the role of LC in central chemosensitivity, we examined the effects of microinjection of solutions with different pH values (7.2, 7.4, 7.6, 7.8, and 8.0) into the nucleus. Our main findings were that 1) a marked increase in c-fos-positive cells in the LC was induced after 3 h of breathing a hypercarbic gas mixture; 2) chemical lesions in the LC attenuated the increase of the ventilatory response to hypercarbia but did not affect ventilation under resting conditions; and 3) microinjection with acid solutions (pH = 7.2, 7.4, and 7.6) into the LC elicit...Continue Reading

References

Nov 1, 1978·The American Journal of Physiology·B M Hitzig, D C Jackson
Feb 1, 1992·Respiration Physiology·L G BrancoA Hoffmann
Jan 1, 1991·Annual Review of Physiology·W W Burggren, A W Pinder
Aug 1, 1987·Respiration Physiology·M KruhøfferK Johansen
Sep 1, 1985·The American Journal of Physiology·B M HitzigD C Jackson
Jan 1, 1973·Acta Anatomica·A Hoffmann
Jun 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·W K MilsomG R Gabbott
Jan 1, 1994·Respiration Physiology·R Kinkead, W K Milsom
Sep 1, 1993·Respiration Physiology·L G BrancoA Hoffmann
Jul 1, 1993·Journal of Applied Physiology·E L CoatesE E Nattie
Jan 1, 1996·Journal of Applied Physiology·D G BernardE E Nattie
May 31, 1996·Neuroreport·O MarínA González
Aug 1, 1996·Respiration Physiology·M A HaxhiuN S Cherniack
Feb 1, 1997·The American Journal of Physiology·R Kinkead, W K Milsom
Nov 22, 1997·The Journal of Comparative Neurology·L J TeppemaC Olievier
Jan 12, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·K C Bícego-Nahas, L G Branco
May 11, 2000·Journal of Neurophysiology·I C SolomonJ A Neubauer
Mar 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C S TorgersonJ E Remmers
Jun 5, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·UNKNOWN World Medical Association General Assembly.
Jun 19, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·L H Gargaglioni, L G Branco
Dec 12, 2001·Respiration Physiology·E E Nattie
Apr 17, 2002·The Journal of Physiology·R J A WilsonJ E Remmers
Jul 11, 2002·Respiratory Physiology & Neurobiology·W K Milsom
Jul 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·UNKNOWN World Medical Association, UNKNOWN American Physiological Society
Sep 5, 2002·Respiratory Physiology & Neurobiology·Luciane H GargaglioniL G S Branco
Feb 7, 2003·Journal of Applied Physiology·Barbara E TaylorJ C Leiter
Jan 1, 1958·Pflügers Archiv : European journal of physiology·H H LOESCHCKEK H GERTZ
Apr 28, 2004·Respiratory Physiology & Neurobiology·T WangW K Milsom
May 18, 2004·The Journal of Physiology·Maria C AlmeidaLuiz G S Branco
Nov 5, 2004·American Journal of Physiology. Cell Physiology·Robert W PutnamNicola A Ritucci
Feb 25, 2005·Experimental Physiology·G B RichersonA Diez-Sampedro
Feb 25, 2005·Experimental Physiology·Patrice G GuyenetDaniel K Mulkey

❮ Previous
Next ❯

Citations

Feb 12, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Cosima PorteusWilliam K Milsom
Mar 2, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Jessica McAneneyStephen G Reid
May 4, 2010·Respiratory Physiology & Neurobiology·Luciane H GargaglioniRobert W Putnam
Nov 26, 2015·Neuroscience·Débora de CarvalhoLuciane H Gargaglioni
Jun 14, 2008·Respiratory Physiology & Neurobiology·Luciane H GargaglioniLuiz Guilherme S Branco
Dec 11, 2007·Respiratory Physiology & Neurobiology·Kajapiratha SrivaratharajahStephen G Reid
Dec 5, 2006·Respiratory Physiology & Neurobiology·Jessica McAneney, Stephen G Reid
Sep 5, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Luciane H Gargaglioni, William K Milsom
Apr 17, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Elisa M FonsecaLuciane H Gargaglioni
Sep 4, 2014·Frontiers in Physiology·Débora de CarvalhoLuciane H Gargaglioni
Apr 24, 2018·Psychophysiology·Michael Christopher MelnychukIan H Robertson
Jul 13, 2016·The Journal of Experimental Biology·Lucas A ZenaLynn K Hartzler
Apr 20, 2016·The Journal of Experimental Biology·Joseph M Santin, Lynn K Hartzler
Sep 23, 2018·Experimental Physiology·Eliandra N da SilvaMirela B Dias
Oct 11, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joseph M SantinLynn K Hartzler
Apr 3, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joseph M Santin, Lynn K Hartzler
Oct 15, 2021·Current Biology : CB·Alejandro Osorio-ForeroAnita Lüthi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.