Locus coeruleus lesions decrease oxytocin and vasopressin release induced by hemorrhage

Neurochemical Research
Gisele V RodovalhoJ A Anselmo-Franci

Abstract

The role of the noradrenergic nucleus Locus Coeruleus (LC) on hemorrhage-induced vasopressin (AVP) and oxytocin (OT) secretion was examined. Rats with LC lesion were submitted to three 1-min hemorrhage sessions at 5-min intervals; 15% of the total blood volume was withdrawn in each session. OT and AVP were measured in plasma, paraventricular (PVN) and supraoptic (SON) nuclei and in posterior pituitary (PP). LC Lesion did not affect basal plasma AVP or OT levels, but partly blocked the increase in plasma AVP and OT induced by hemorrhage. Hemorrhage produced decreases in content of AVP and OT in the PVN and SON and increased levels in the PP. These responses were attenuated in the lesioned group, but only in the PVN and PP. Data suggest a stimulatory role of the inputs from LC to PVN neurons on hemorrhage-induced OT and AVP secretion and that, this pathway is critical in the hypo-volemic neuroendocrine reflex.

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Citations

Mar 1, 2008·Endocrinology·Marcelo P BernuciJanete A Anselmo-Franci
Jun 3, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andre S MecawiJose Antunes-Rodrigues
Dec 23, 2017·Brain : a Journal of Neurology·Michael SommerauerPer Borghammer
Mar 11, 2021·Case Reports in Critical Care·Mohammed M UddinNoreen F Rossi
May 5, 2021·Journal of Neural Transmission·Filippo Sean GiorgiFrancesco Fornai
Jul 2, 2021·Brain : a Journal of Neurology·Christopher E J DopplerMichael Sommerauer

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