Locus coeruleus response to single-prolonged stress and early intervention with intranasal neuropeptide Y

Journal of Neurochemistry
Esther L SabbanLidia I Serova

Abstract

Dysregulation of the central noradrenergic system is a core feature of post-traumatic stress disorder (PTSD). Here, we examined molecular changes in locus coeruleus (LC) triggered by single-prolonged stress (SPS) PTSD model at a time when behavioral symptoms are manifested, and the effect of early intervention with intranasal neuropeptide Y (NPY). Immediately following SPS stressors, male SD rats were administered intranasal NPY (SPS/NPY) or vehicle (SPS/V). Seven days later, TH protein, but not mRNA, was elevated in LC only of the SPS/V group. Although 90% of TH positive cells expressed GR, its levels were unaltered. Compared to unstressed controls, LC of SPS/V, but not SPS/NPY, expressed less Y2 receptor mRNA with more CRHR1 mRNA in subset of animals, and elevated corticotropin-releasing hormone (CRH) in central nucleus of amygdala. Following testing for anxiety on elevated plus maze (EPM), there were significantly increased TH, DBH and NPY mRNAs in LC of SPS-treated, but not previously unstressed animals. Their levels highly correlated with each other but not with behavioral features on EPM. Thus, SPS triggers long-term noradrenergic activation and higher sensitivity to mild stressors, perhaps mediated by the up-regulation i...Continue Reading

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Citations

Dec 1, 2015·Neuropeptides·Esther L SabbanLidia I Serova
Jul 6, 2016·Experimental Neurology·Sarah N SchmeltzerRenu Sah
Jul 16, 2016·Journal of Natural Medicines·Bombi LeeDae-Hyun Hahm
Feb 26, 2019·Frontiers in Behavioral Neuroscience·Roxanna J NahviEsther L Sabban
Jul 25, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Geraldine ZenzPeter Holzer
Aug 22, 2017·Frontiers in Endocrinology·Annika Thorsell, Aleksander A Mathé
Jun 30, 2019·Annals of the New York Academy of Sciences·Chiso NwokaforEsther L Sabban
Sep 11, 2017·Cellular and Molecular Neurobiology·Esther L SabbanIrit Akirav
Aug 3, 2020·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·José Luís AlvesAnabela Mota Pinto
Sep 22, 2020·Brain and Neuroscience Advances·Laurel S MorrisJames W Murrough
Nov 6, 2020·The International Journal of Neuropsychopharmacology·Dayan KnoxEmily Moulton

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