Locus of the lethal event in the serum bactericidal reaction.

Journal of Bacteriology
D S FeingoldH M Kuritz

Abstract

Hypertonic sucrose inhibited the bactericidal activity of lysozyme-free serum against a rough strain of Escherichia coli. The duration of the inhibition correlated with the duration of plasmolysis caused by the sucrose. Although the lethal action of the serum was delayed, the prompt release of alkaline phosphatase by the cells suggested that nonlethal damage to the cell wall had taken place under these conditions. In contrast, the crypticity of the cells for beta-galactosidase did not deteriorate until the viability of the bacteria began to decrease. It is concluded that the primary site of action of serum is at the bacterial cell wall; however, in the absence of lysozyme, the lethal event was subsequent damage to the bacterial cell membrane.

References

Dec 1, 1967·Journal of Bacteriology·H C Neu, J Chou
Jun 16, 1967·Science·L A Heppel
Aug 11, 1964·Biochemical and Biophysical Research Communications·M Cashel, E Freese
Dec 1, 1968·Journal of Bacteriology·D S FeingoldH M Kuritz
May 1, 1967·Journal of Bacteriology·A Iannetta, R J Wedgwood

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Citations

Jan 1, 1986·Scandinavian Journal of Urology and Nephrology·M ArpiB Timmermann
Nov 20, 1969·The New England Journal of Medicine·D S Feingold
Dec 19, 2001·Infection and Immunity·Michael G Barnes, Alison A Weiss
Dec 1, 1968·Journal of Bacteriology·D S FeingoldH M Kuritz
Jun 1, 1977·Bacteriological Reviews·D M Donaldson, J G Tew
Jan 1, 1971·Infection and Immunity·L Melching, S I Vas
Aug 11, 1983·Biochimica Et Biophysica Acta·S Bhakdi, J Tranum-Jensen
Nov 1, 1972·Infection and Immunity·H Pruul, B L Reynolds
Mar 1, 1974·Bacteriological Reviews·J W CostertonK J Cheng
Dec 1, 1971·Infection and Immunity·B L Reynolds, H Pruul
Oct 1, 1978·Infection and Immunity·A M Friedlander
Dec 1, 1983·Infection and Immunity·H P KrollP W Taylor
Sep 1, 1976·Infection and Immunity·A M Reynard, M E Beck
Jan 1, 1987·Infection and Immunity·S BhakdiJ Parrisius
Jan 1, 1983·Infection and Immunity·P W Taylor, H P Kroll
Oct 1, 1977·Infection and Immunity·D L KreutzerA A Hirata

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