PMID: 698045Aug 1, 1978Paper

Lodgement and extravasation of tumour cells in blood-borne metastasis: an electron microscope study

British Journal of Cancer
M Kinjo

Abstract

Soon after i.v. injection of ascites hepatoma cells of rat, 3 types of tumour-cell emboli were found in arterioles and capillaries of the lung. The first type had marked aggregation of platelets and deposition of fibrin. Many were seen when tumour cells with high thromboplastic activity (AH 130) were injected, and were often followed by detachment and fragmentation of endothelial cells. The second type had loosely aggregated platelets and the third type had no aggregation of platelets or deposition of fibrin. The latter 2 types were mainly seen when the tumour cells with low thromboplastic activity [AH 130 F(N)] were injected, and they did not accompany severe structural changes of the endothelial cells. Tumour cell-platelet complexes appeared to be induced by tissue thromboplastin released from tumour cells rather than from the endothelial cells. One to 6 h after injection of AH 130, tumour cells were found beneath the endothelial cells detached from the basement membrane in areas with microthrombi. Breaching of the endothelial cells with the processes of tumour cells was also seen then. Intrusion of the processes of tumour cells into the endothelial cells was noted in groups injected with either AH 130 or AH 130 F(N), but not...Continue Reading

Citations

Jan 1, 1988·Clinical & Experimental Metastasis·K LapisL A Liotta
Jul 1, 1985·Clinical & Experimental Metastasis·W A TurnerJ D Taylor
Apr 4, 2014·Cancer Metastasis Reviews·David G MenterKenneth V Honn
Mar 1, 1991·Clinical & Experimental Metastasis·C F von Essen
Apr 1, 1989·Cell Biophysics·L Weiss, G W Schmid-Schönbein
Apr 1, 1983·Clinical & Experimental Metastasis·R G RussoL A Liotta
Jan 1, 1983·Cancer Metastasis Reviews·H F DvorakA M Dvorak
Dec 15, 1982·International Journal of Cancer. Journal International Du Cancer·M F Di Renzo, S Bretti
Mar 1, 1989·Clinical & Experimental Metastasis·L WeissK V Honn
Sep 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K TanigawaL M Stoolman
Jun 10, 2016·Journal of Cell Science·Nawal BendrisSandra L Schmid
Sep 12, 2015·International Journal of Cancer. Journal International Du Cancer·Nailin Li
Oct 1, 1993·Japanese Journal of Cancer Research : Gann·J R SheuT F Huang
Jan 1, 1983·Annals of the New York Academy of Sciences·L Weiss, D Glaves
Feb 20, 1993·International Journal of Cancer. Journal International Du Cancer·D Zhu, B U Pauli
Jul 22, 2017·Cancer Metastasis Reviews·David G MenterKenneth V Honn
Apr 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M W SwaimT F Huang
Oct 14, 2008·Trends in Cell Biology·R Grant Rowe, Stephen J Weiss

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Coagulation Signaling Pathways

Coagulation is the process by which a blood clot is formed. This process includes both the formation of a platelet plug as well as a cascade of clotting factors resulting in the formation of fibrin strands. Find the latest research on coagulation signaling pathways here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.