Logarithmic dose transformation in epidemiologic dose-response analysis: use with caution

Regulatory Toxicology and Pharmacology : RTP
Michael E Ginevan, Deborah K Watkins

Abstract

Dose-response models based on the logarithm of dose or exposure are utilized in the analysis of both toxicological and epidemiologic data. While the applications are similar, fundamental differences in the studies conducted by each discipline affects the interpretation of the use of the logarithmic dose transformation. Using numerical illustrations and examples from the literature, this paper explores the implications of using logarithmic dose transformation in epidemiologic studies and provides some caveats for consideration in interpreting epidemiologic studies based upon logarithmic dose transformation.

References

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Nov 19, 2003·Regulatory Toxicology and Pharmacology : RTP·Philip ColeJack S Mandel
Nov 30, 2006·Epidemiology·Melissa C FriesenPaul A Demers
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Jan 29, 2010·Environmental Health Perspectives·Stephanie M EngelMary S Wolff

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Citations

Jun 20, 2014·Journal of Exposure Science & Environmental Epidemiology·Michael E GinevanDeborah K Watkins
Mar 29, 2011·Annals of Epidemiology·Patricia A BufflerDeborah K Watkins
Dec 21, 2014·International Journal of Epidemiology·Michael E GinevanJohn H Ross
Dec 21, 2014·International Journal of Epidemiology·Steven D Stellman, Jeanne M Stellman
Mar 29, 2019·Critical Reviews in Toxicology·S Stanley Young, Warren B Kindzierski
Oct 11, 2020·International Journal of Environmental Research and Public Health·Albeliz Santiago-ColónJohn Howard

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