Logic of Wg and Dpp induction of distal and medial fates in the Drosophila leg

Development
Carlos Estella, Richard S Mann

Abstract

Drosophila leg development requires the cooperation of two secreted signals, Decapentaplegic (Dpp) and Wingless (Wg), to form the proximodistal (PD) axis. Wg and Dpp are also required to pattern the dorsoventral (DV) axis of the leg. Here, we show that Distalless (Dll) and dachshund (dac), genes expressed at different positions along the PD axis, are activated by Wg signaling and repressed by Brinker (Brk), a transcriptional repressor in the Dpp pathway. The levels of both Brk and Wg determine which of these PD genes is activated. Surprisingly, Brk does not play a role in DV axis specification in the leg, suggesting that Dpp uses two distinct mechanisms for generating the PD and DV axes. Based on these results, we present a model for how Dpp and Wg, which are present as dorsal and ventral gradients, respectively, induce nearly circular domains of gene expression along the PD axis.

References

Aug 1, 1991·Current Opinion in Genetics & Development·P W Ingham
Jul 1, 1990·Genes & Development·R D St JohnstonW M Gelbart
Jan 1, 1994·Methods in Cell Biology·A H BrandN Perrimon
Jan 22, 1993·Science·J P CousoA Martínez-Arias
Feb 26, 1993·Cell·G Struhl, K Basler
Jul 10, 1997·Nature·T Lecuit, S M Cohen
Aug 14, 1997·Nature·N ShubinS Carroll
Oct 12, 2000·Nature Cell Biology·T MartyM Affolter
Mar 16, 2001·Current Opinion in Genetics & Development·M Merika, D Thanos
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·G Morata
Mar 23, 2001·The Journal of Biological Chemistry·H KirkpatrickA Laughon
Mar 27, 2001·Nucleic Acids Research·H BrantjesH Clevers
Apr 17, 2001·Science·K A GussS B Carroll
Jul 4, 2001·The EMBO Journal·M AffolterA Jaźwińska
Aug 30, 2002·Current Opinion in Genetics & Development·Richard S Mann, Sean B Carroll
Feb 6, 2004·Development·Tetsuya Tabata, Yuki Takei
Aug 7, 2004·Developmental Cell·George PyrowolakisMarkus Affolter
Mar 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sorin Istrail, Eric H Davidson
Sep 21, 2005·Developmental Biology·Melissa Moser, Gerard Campbell

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Citations

Dec 22, 2009·Development Genes and Evolution·Daniela GrossmannNikola-Michael Prpic
May 25, 2011·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Nicholas E Baker, Lucy C Firth
Jan 30, 2015·Evolution & Development·Ralf JanssenGraham E Budd
Aug 26, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Diane Egger-Adam, Vladimir L Katanaev
Aug 28, 2012·Developmental Biology·Daniela Grossmann, Nikola-Michael Prpic
Feb 16, 2011·Developmental Biology·Máximo Ibo GalindoJuan Pablo Couso
May 18, 2011·Developmental Biology·Youngwook AhnPamela J Mitchell
Apr 13, 2013·PloS One·Weiping ShenNicholas Harden
Feb 18, 2017·ELife·Olivia SchwarzJan Pielage
Jul 18, 2018·Journal of Developmental Biology·Mireya Ruiz-LosadaCarlos Estella
Jan 29, 2017·Cold Spring Harbor Perspectives in Biology·Ambuj UpadhyayMichael B O'Connor
Aug 20, 2021·Frontiers in Cell and Developmental Biology·Mireya Ruiz-LosadaCarlos Estella
Sep 20, 2008·Developmental Biology·Jose Ignacio Pueyo, Juan Pablo Couso

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