Lognormal firing rate distribution reveals prominent fluctuation-driven regime in spinal motor networks

BioRxiv : the Preprint Server for Biology
Peter C Petersen, Rune W Berg


When spinal circuits generate rhythmic movements it is important that the neuronal activity remains within stable bounds to avoid saturation and to preserve responsiveness. In what dynamical regime does the neuronal population operate in order to achieve this? Here, we simultaneously recorded from hundreds of neurons in lumbar spinal circuits and establish the neuronal fraction that operates within either a mean driven or a fluctuation driven regime during generation of multiple motor behaviors. We find a rich diversity of firing rates across the neuronal population as reflected in a lognormal distribution and demonstrate that half of the neurons spend at least 50% of the time in the fluctuation driven regime regardless of behavior. Since neurons in this regime have a supralinear input output curve, which enhances sensitivity, whereas the mean driven regime reduces sensitivity, this fraction may reflect a fine trade off between stability and sensitivity in order to maintain flexibility across motor behaviors.

Related Concepts

Enzyme Stability
Structure of Spinal Motor Nerve

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
Alain Frigon
Zhurnal vyssheĭ nervnoĭ deiatelnosti imeni I P Pavlova
© 2021 Meta ULC. All rights reserved