Loin pain hematuria syndrome

Clinical Kidney Journal
Adeel S ZubairMikel Prieto

Abstract

Loin pain hematuria syndrome (LPHS), first described in 1967, is a rare pain syndrome, which is not well understood. The syndrome is characterized by severe intermittent or persistent flank pain, either unilateral or bilateral, associated with gross or microscopic hematuria. LPHS is a diagnosis of exclusion as there still is not a consensus of validated diagnostic criteria, though several criteria have been proposed. The wide differential diagnosis would suggest a meticulous yet specific diagnostic work-up depending on the individual clinical features and natural history. Several mechanisms regarding the pathophysiology of LPHS have been proposed but without pinpointing the actual causative etiology, the treatment remains symptomatic. Treatment modalities for LPHS are diverse including simple analgesia, opioid analgesic and kidney autotransplantation. This review article summarizes the current understanding regarding the pathophysiology of LPHS along with the steps required for proper diagnosis and a discussion of the different therapeutic approaches for LPHS.

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Citations

Apr 23, 2016·The Korean Journal of Pain·Andrew Kristian Grech
Oct 21, 2016·The Journal of Clinical Hypertension·Amy E BurchellAngus K Nightingale
Dec 9, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Xander Zuidema, Johannes W L C Schapendonk
Sep 22, 2019·Clinical Transplantation·Leigh-Anne DaleLloyd E Ratner
Mar 28, 2019·Journal of Cellular Physiology·Reza Alizadeh, Ziba Aghsaie Fard
Apr 13, 2019·International Urology and Nephrology·Jeffrey CampsenBlake Hamilton
Jun 20, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Agustina AlonsoFernando Santos
Jan 27, 2021·Current Pain and Headache Reports·Ivan UritsAlan D Kaye
Nov 1, 2020·Current Hypertension Reports·Leslie Marisol Lugo-GavidiaMarkus P Schlaich

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Methods Mentioned

BETA
biopsies
biopsy

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